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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03855naa a2200505 4500 | |
| 001 | oai:lup.lub.lu.se:837ba4cf-b3ba-41cc-b4a2-aa1ce16da701 | |
| 003 | SwePub | |
| 008 | 160401s2009 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:119187680 | |
| 024 | 7 | a https://lup.lub.lu.se/record/14784112 URI |
| 024 | 7 | a https://doi.org/10.1042/BST03708142 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1191876802 URI |
| 040 | a (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a kon2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Svartengren, Magnusu Karolinska Institutet4 aut |
| 245 | 1 0 | a Twins studies as a model for studies on the interaction between smoking and genetic factors in the development of chronic bronchitis |
| 264 | 1 | c 2009 |
| 520 | a Smoking is the main risk factor for COPD (chronic obstructive pulmonary disease) but genetic factors are of importance, since only a subset of smokers develops the disease. Sex differences have been suggested both in disease prevalence and response to environmental exposures. Furthermore, it has been shown that acquisition of 'addiction' to smoking is partly genetically mediated. Disease cases and smoking habits were identified in 44919 twins aged > 40 years from the Swedish Twin Registry. Disease was defined as self-reported chronic bronchitis or emphysema, or recurrent cough with phlegm. The results showed that chronic bronchitis seems to be more prevalent among females, and that the heritability estimate for chronic bronchitis was a moderate 40% and only 14% of the genetic influences were shared by smoking. In addition, 392 twins have been invited to a clinical investigation to evaluate: (i) to what extent genetic factors contribute to individual differences (variation) in FEV1 (forced expiratory volume in 1 s), vital capacity and l (diffusion capacity), taking sex into consideration, and (ii) whether smoking behaviour and respiratory symptoms influence these estimates. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 653 | a inflammatory marker | |
| 653 | a chronic obstructive pulmonary disease (COPD) | |
| 653 | a heritability | |
| 653 | a multi-slice computed tomography (MSCT) | |
| 653 | a smoking | |
| 653 | a twin | |
| 700 | 1 | a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen |
| 700 | 1 | a Anderson, Martinu Karolinska Institutet4 aut |
| 700 | 1 | a Hallberg, Jennyu Karolinska Institutet4 aut |
| 700 | 1 | a Edula, Goutham4 aut |
| 700 | 1 | a de Verdier, Maria Gerhardsson4 aut |
| 700 | 1 | a Dahlback, Magnus4 aut |
| 700 | 1 | a Lindberg, Claes M.4 aut |
| 700 | 1 | a Forsman-Semb, Kristina4 aut |
| 700 | 1 | a Nihlén, Ulfu Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)lung-uni |
| 700 | 1 | a Fehniger, Thomas E.4 aut |
| 710 | 2 | a Karolinska Institutetb Kardiovaskulär forskning - epidemiologi4 org |
| 773 | 0 | t Biochemical Society Transactionsg 37, s. 814-818q 37<814-818x 1470-8752x 0300-5127 |
| 856 | 4 | u http://dx.doi.org/10.1042/BST0370814y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1478411 |
| 856 | 4 8 | u https://doi.org/10.1042/BST0370814 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:119187680 |
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