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Ex vivo dual perfus...
Ex vivo dual perfusion of an isolated human placenta cotyledon : Towards protocol standardization and improved inter-centre comparability
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- Schneider, Henning (author)
- Bern University Hospital
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- Albrecht, Christiane (author)
- University of Bern
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- Ahmed, Mahmoud S. (author)
- University of Texas Medical Branch
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- Broekhuizen, Michelle (author)
- Erasmus University Medical Center
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- Aengenheister, Leonie (author)
- Swiss Federal Laboratories for Materials Science and Technology
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- Buerki-Thurnherr, Tina (author)
- Swiss Federal Laboratories for Materials Science and Technology
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- Danser, A. H.Jan (author)
- Erasmus University Medical Center
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- Gil, Sophie (author)
- Université Paris Cité
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- Hansson, Stefan R. (author)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Greupink, Rick (author)
- Radboud University Medical Center
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- Lewis, Rohan M. (author)
- University of Southampton
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- Markert, Udo R. (author)
- Universitätsklinikum Jena
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- Mathiesen, Line (author)
- University of Copenhagen
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- Powles-Glover, Nicola (author)
- AstraZeneca, UK
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- Wadsack, Christian (author)
- Medical University of Graz
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- Brownbill, Paul (author)
- Manchester Academic Health Science Centre,University of Manchester
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English 7 s.
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In: Placenta. - : Elsevier BV. - 0143-4004. ; 126, s. 83-89
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Abstract
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- Since the full development of the ex vivo dual perfusion model of the human placenta cotyledon, the technique has provided essential insight into how nutrients, lipids, gases, immunoglobulins, endocrine agents, pharmaceuticals, chemicals, nanoparticles, micro-organisms and parasites might traverse the maternofetal barrier. Additionally, the model has been instrumental in gaining a better understanding of the regulation of vascular tone, endocrinology and metabolism within this organ. The human placenta is unique amongst species in its anatomy and transfer modalities. This orthologous diversity therefore requires an appropriate consideration of placental transfer rates of compounds, particles and micro-organisms specific to humans. Different research centres have adapted this model with a wide variation in perfusion parameters, including in the establishment of perfusion, perfusate composition, gassing regime, cannulation method, flow rates, perfused tissue mass, and also in the application of quality control measures. The requirement to harmonise and standardise perfusion practice between centres is largely driven by the need to obtain consistency in our understanding of placental function, but also in the qualification of the model for acceptance by regulatory agencies in drug and toxicology testing. A pilot study is proposed, aiming to describe how existing inter-centre variation in perfusion methodology affects placental metabolism, protein synthesis, oxygen consumption, the materno-fetal transfer of key molecular markers, and placental structure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Function
- Perfusion
- Placenta
- Regulatory
- Standardisation
- Transfer
Publication and Content Type
- art (subject category)
- ref (subject category)
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Placenta
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- By the author/editor
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Schneider, Henni ...
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Albrecht, Christ ...
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Ahmed, Mahmoud S ...
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Broekhuizen, Mic ...
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Aengenheister, L ...
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Buerki-Thurnherr ...
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Danser, A. H.Jan
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Gil, Sophie
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Hansson, Stefan ...
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Greupink, Rick
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Lewis, Rohan M.
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Markert, Udo R.
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Mathiesen, Line
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Powles-Glover, N ...
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Wadsack, Christi ...
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Brownbill, Paul
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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Placenta
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Lund University