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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004718naa a2200733 4500
001oai:lup.lub.lu.se:850ab45b-5a68-45b8-8657-aae3449094d7
003SwePub
008160401s2009 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/13128682 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-08-05392 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a McKay, James D.4 aut
2451 0a Vitamin D Receptor Polymorphisms and Breast Cancer Risk: Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
264 1c 2009
520 a Background: Vitamin D is hypothesized to lower the risk of breast cancer by inhibiting cell proliferation via the nuclear vitamin D receptor (VDR). Two common single nucleotide polymorphisms (SNP) in the VDR gene (VDR), rs154441.0 (BsmI), and rs2228570 (FokI), have been inconsistently associated with breast cancer risk. Increased risk has been reported for the FokIff genotype, which encodes a less transcriptionally active isoform of VDR, and reduced risk has been reported for the BsmI BB genotype, a SNP in strong linkage disequilibrium with a 3'-untranslated region, which may influence VDR mRNA stability. Methods: We pooled data from 6 prospective studies in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium to examine associations between these SNPs and breast cancer among >6,300 cases and 8,100 controls for each SNP using conditional logistic regression. Results: The odds ratio (OR) for the rs2228570 (FokI) ff versus FF genotype in the overall population was statistically significantly elevated [OR, 1-1.6; 95% confidence interval (95% CI), 1.04-1.28] but was weaker once data from the cohort with previously published positive findings were removed (OR, 1.1.0; 95% CI, 0.981.24). No association was noted between rs1544410 (Bsm I) BB and breast cancer risk overall (OR, 0.98; 95% CI, 0.89-1.09), but the BB genotype was associated with a significantly lower risk of advanced breast cancer (OR, 0.74; 95% CI, 0.60-0.92). Conclusions: Although the evidence for independent contributions of these variants to breast cancer susceptibility remains equivocal, future large studies should integrate genetic variation in VDR with biomarkers of vitamin D status. (Cancer Epidemiol Biomarkers Prev 2009;18(1):297-305)
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a McCullough, Marjorie L.4 aut
7001 a Ziegler, Regina G.4 aut
7001 a Kraft, Peter4 aut
7001 a Saltzman, Barbara S.4 aut
7001 a Riboli, Elio4 aut
7001 a Barricarte, Aurelio4 aut
7001 a Berg, Christine D.4 aut
7001 a Berglund, Göranu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-gbe
7001 a Bingham, Sheila4 aut
7001 a Brustad, Magritt4 aut
7001 a Bueno-de-Mesquita, H. Bas4 aut
7001 a Burdette, Laurie4 aut
7001 a Buring, Julie4 aut
7001 a Calle, Eugenia E.4 aut
7001 a Chanock, Stephen J.4 aut
7001 a Clavel-Chapelon, Francoise4 aut
7001 a Cox, David G.4 aut
7001 a Dossus, Laure4 aut
7001 a Feigelson, Heather Spencer4 aut
7001 a Haiman, Christopher A.4 aut
7001 a Hankinson, Susan E.4 aut
7001 a Hoover, Robert N.4 aut
7001 a Hunter, David J.4 aut
7001 a Husing, Anika4 aut
7001 a Kaaks, Rudolph4 aut
7001 a Kolonel, Laurence N.4 aut
7001 a Le Marchand, Loic4 aut
7001 a Linseisen, Jakob4 aut
7001 a McCarty, Catherine A.4 aut
7001 a Overvad, Kim4 aut
7001 a Panico, Salvatore4 aut
7001 a Purdue, Mark P.4 aut
7001 a Stram, Daniel O.4 aut
7001 a Stevens, Victoria L.4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Willett, Walter C.4 aut
7001 a Yuenger, Jeffrey4 aut
7001 a Thun, Michael J.4 aut
7102 a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org
7730 t Cancer Epidemiology Biomarkers & Preventiong 18:1, s. 297-305q 18:1<297-305x 1538-7755
8564 u http://dx.doi.org/10.1158/1055-9965.EPI-08-0539y FULLTEXT
8564 8u https://lup.lub.lu.se/record/1312868
8564 8u https://doi.org/10.1158/1055-9965.EPI-08-0539

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