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Health-related qual...
Health-related quality of life in patients with haemophilia and inhibitors on prophylaxis with anti-inhibitor complex concentrate: results from the Pro-FEIBA study
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Gringeri, A. (author)
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Leissinger, C. (author)
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Cortesi, P. A. (author)
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Jo, H. (author)
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Fusco, F. (author)
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Riva, S. (author)
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Antmen, B. (author)
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- Berntorp, Erik (author)
- Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups
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Biasoli, C. (author)
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Carpenter, S. (author)
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Kavakli, K. (author)
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Morfini, M. (author)
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Negrier, C. (author)
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Rocino, A. (author)
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Schramm, W. (author)
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Windyga, J. (author)
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Zulfikar, B. (author)
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Mantovani, L. G. (author)
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(creator_code:org_t)
- 2013-06-04
- 2013
- English.
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In: Haemophilia. - : Wiley. - 1351-8216. ; 19:5, s. 736-743
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Patients with haemophilia A and inhibitors are at high risk for severe bleeding, progression of joint disease and deterioration of health-related quality of life (HRQoL). To determine the impact of prophylaxis with an activated prothrombin complex concentrate (aPCC) on HRQoL, HRQoL was assessed using the Short-Form (SF)-36 Health Survey and the EQ-5D questionnaire in subjects 14years participating in a prospective, randomized, crossover study comparing 6months of aPCC prophylaxis with 6months of on-demand therapy. Eighteen of 19 patients completed the survey or questionnaire before and after the on-demand therapy and prophylaxis periods. A general trend towards improved HRQoL after prophylaxis was observed for the 18 evaluable patients in all SF-36 dimensions except for vitality/energy and physical functioning. After prophylaxis, good responders,' defined as patients experiencing 50% reduction in bleeding, exhibited statistically and clinically significant differences in the physical component score (P=0.021), role - physical (P=0.042), bodily pain (P=0.015), and social functioning (P=0.036). Similarly, the EQ-5D health profile showed a trend towards improvement after prophylaxis in all evaluable patients. Among the good responders, improvements did not differ from those observed after on-demand treatment. EQ visual analogue scale values were slightly improved following prophylaxis for all evaluable patients and the EQ-5D utility index improved in the good responders only. During prophylaxis, patients missed significantly fewer days from school or work because of bleeding than during on-demand treatment (P=0.01). In conclusion, by significantly reducing bleeding frequency in good responders, aPCC prophylaxis improved HRQoL compared with on-demand treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- activated prothrombin complex concentrate
- health-related quality of
- life
- haemophilia
- inhibitors
- prophylaxis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Gringeri, A.
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Leissinger, C.
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Cortesi, P. A.
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Jo, H.
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Fusco, F.
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Riva, S.
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show more...
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Antmen, B.
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Berntorp, Erik
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Biasoli, C.
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Carpenter, S.
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Kavakli, K.
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Morfini, M.
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Negrier, C.
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Rocino, A.
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Schramm, W.
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Windyga, J.
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Zulfikar, B.
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Mantovani, L. G.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Haemophilia
- By the university
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Lund University