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The AsiDNA™ decoy mimicking DSBs protects the normal tissue from radiation toxicity through a DNA-PK/p53/p21-dependent G1/S arrest

Sesink, Anouk (author)
University of Paris-Saclay,Lausanne University Hospital,Curie Institute, Paris
Becerra, Margaux (author)
University of Paris-Saclay,Curie Institute, Paris
Ruan, Jia Ling (author)
University of Oxford
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Leboucher, Sophie (author)
Curie Institute, Paris
Dubail, Maxime (author)
University of Paris-Saclay,Curie Institute, Paris
Heinrich, Sophie (author)
Curie Institute, Paris,University of Paris-Saclay
Jdey, Wael (author)
Petersson, Kristoffer (author)
Lund University,Lunds universitet,Radiotherapy Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,University of Oxford,Skåne University Hospital
Fouillade, Charles (author)
University of Paris-Saclay,Curie Institute, Paris
Berthault, Nathalie (author)
University of Paris-Saclay,Curie Institute, Paris
Dutreix, Marie (author)
Curie Institute, Paris,University of Paris-Saclay
Girard, Pierre Marie (author)
University of Paris-Saclay,Curie Institute, Paris
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 (creator_code:org_t)
2024
2024
English.
In: NAR Cancer. - 2632-8674. ; 6:1
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • AsiDNA™, a cholesterol-coupled oligonucleotide mimicking double-stranded DNA breaks, was developed to sensitize tumour cells to radio- and chemotherapy. This drug acts as a decoy hijacking the DNA damage response. Previous studies have demonstrated that standalone AsiDNA™ administration is well tolerated with no additional adverse effects when combined with chemo- and/or radiotherapy. The lack of normal tissue complication encouraged further examination into the role of AsiDNA™ in normal cells. This research demonstrates the radioprotective properties of AsiDNA™. In vitro, AsiDNA™ induces a DNA-PK/p53/p21-dependent G1/S arrest in normal epithelial cells and fibroblasts that is absent in p53 deficient and proficient tumour cells. This cell cycle arrest improved survival after irradiation only in p53 proficient normal cells. Combined administration of AsiDNA™ with conventional radiotherapy in mouse models of late and early radiation toxicity resulted in decreased onset of lung fibrosis and increased intestinal crypt survival. Similar results were observed following FLASH radiotherapy in standalone or combined with AsiDNA™. Mechanisms comparable to those identified in vitro were detected both in vivo, in the intestine and ex vivo, in precision cut lung slices. Collectively, the results suggest that AsiDNA™ can partially protect healthy tissues from radiation toxicity by triggering a G1/S arrest in normal cells.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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