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Search: onr:"swepub:oai:lup.lub.lu.se:85e7b22c-58cd-436d-a47e-5894ff96e83b" > The α-synuclein PET...

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  • Smith, RubenLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Regeneration in Movement Disorders,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital (author)

The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023

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  • LIBRIS-ID:oai:lup.lub.lu.se:85e7b22c-58cd-436d-a47e-5894ff96e83b
  • https://lup.lub.lu.se/record/85e7b22c-58cd-436d-a47e-5894ff96e83bURI
  • https://doi.org/10.1038/s41467-023-42305-3DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154088784URI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve the diagnosis, and ultimately the treatment of α-synuclein-related diseases. Here we show that the PET ligand, [18F]ACI-12589, displays good in vitro affinity and specificity for pathological α-synuclein in tissues from patients with different α-synuclein-related disorders including Parkinson’s disease (PD) and Multiple-System Atrophy (MSA) using autoradiography and radiobinding techniques. In the initial clinical evaluation we include 23 participants with α-synuclein related disorders, 11 with other neurodegenerative disorders and eight controls. In vivo [18F]ACI-12589 demonstrates clear binding in the cerebellar white matter and middle cerebellar peduncles of MSA patients, regions known to be highly affected by α-synuclein pathology, but shows limited binding in PD. The binding statistically separates MSA patients from healthy controls and subjects with other neurodegenerative disorders, including other synucleinopathies. Our results indicate that α-synuclein pathology in MSA can be identified using [18F]ACI-12589 PET imaging, potentially improving the diagnostic work-up of MSA and allowing for detection of drug target engagement in vivo of novel α-synuclein targeting therapies.

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  • Capotosti, Francesca (author)
  • Schain, MartinLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Copenhagen University Hospital,Antaros Medical AB(Swepub:lu)ma0270sc (author)
  • Ohlsson, TomasSkåne University Hospital (author)
  • Vokali, Efthymia (author)
  • Molette, Jerome (author)
  • Touilloux, Tanja (author)
  • Hliva, Valerie (author)
  • Dimitrakopoulos, Ioannis K. (author)
  • Puschmann, AndreasLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk neurogenetik,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Neurogenetics,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-aps (author)
  • Jögi, JonasLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk fysiologi och nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Physiology and Nuclear Medicine, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)klin-jjo (author)
  • Svenningsson, PerKarolinska Institutet,Karolinska University Hospital (author)
  • Andréasson, MattiasKarolinska Institutet,Karolinska University Hospital (author)
  • Sandiego, Christine (author)
  • Russell, David S. (author)
  • Miranda-Azpiazu, PatriciaKarolinska Institute (author)
  • Halldin, ChristerKarolinska Institutet,Karolinska Institute (author)
  • Stomrud, ErikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital(Swepub:lu)med-esr (author)
  • Hall, SaraLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital(Swepub:lu)med-sha (author)
  • Bratteby, KlasKarolinska Institutet,Skåne University Hospital (author)
  • Tampio L’Estrade, ElinaSkåne University Hospital (author)
  • Luthi-Carter, Ruth (author)
  • Pfeifer, Andrea (author)
  • Kosco-Vilbois, Marie (author)
  • Streffer, JohannesUniversity of Antwerp (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital(Swepub:lu)mphy-ohn (author)
  • Neurologi, LundSektion IV (creator_code:org_t)

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  • In:Nature Communications14:12041-1723

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