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- Huss, LinneaLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital (author)
Vitamin D receptor expression in invasive breast tumors and breast cancer survival
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- 2019-07-29
- Springer Science and Business Media LLC,2019
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:85f5a105-d53b-4cec-939c-00d89587e1e8
- https://lup.lub.lu.se/record/85f5a105-d53b-4cec-939c-00d89587e1e8URI
- https://doi.org/10.1186/s13058-019-1169-1DOI
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- Language:English
- Summary in:English
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- Background: Vitamin D has been suggested to prevent and improve the prognosis of several cancers, including breast cancer. We have previously shown a U-shaped association between pre-diagnostic serum levels of vitamin D and risk of breast cancer-related death, with poor survival in patients with the lowest and the highest levels respectively, as compared to the intermediate group. Vitamin D exerts its functions through the vitamin D receptor (VDR), and the aim of the current study was to investigate if the expression of VDR in invasive breast tumors is associated with breast cancer prognosis. Methods: VDR expression was evaluated in a tissue microarray of 718 invasive breast tumors. Covariation between VDR expression and established prognostic factors for breast cancer was analyzed, as well as associations between VDR expression and breast cancer mortality. Results: We found that positive VDR expression in the nuclei and cytoplasm of breast cancer cells was associated with favorable tumor characteristics such as smaller size, lower grade, estrogen receptor positivity and progesterone receptor positivity, and lower expression of Ki67. In addition, both intranuclear and cytoplasmic VDR expression were associated with a low risk of breast cancer mortality, hazard ratios 0.56 (95% CI 0.34-0.91) and 0.59 (0.30-1.16) respectively. Conclusions: This study found that high expression of VDR in invasive breast tumors is associated with favorable prognostic factors and a low risk of breast cancer death. Hence, a high VDR expression is a positive prognostic factor.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Breast cancer
- Mortality
- Survival
- Tissue microarray
- Vitamin D receptor
Added entries (persons, corporate bodies, meetings, titles ...)
- Butt, Salma TunåLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-smb (author)
- Borgquist, SigneAarhus University(Swepub:lu)ront-sbo (author)
- Elebro, KarinLund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,Breast cancer prevention & intervention,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-kee (author)
- Sandsveden, MalteLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)ma6468sa (author)
- Rosendahl, AnnLund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,Breast cancer prevention & intervention,Lund University Research Groups,Skåne University Hospital(Swepub:lu)onk-aro (author)
- Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)smi-jma (author)
- KirurgiForskargrupper vid Lunds universitet (creator_code:org_t)
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- In:Breast Cancer Research: Springer Science and Business Media LLC21:11465-54111465-542X
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