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  • Karlsson, GöranUniversity College London (author)

The Tetraspanin CD9 Affords High-Purity Capture of All Murine Hematopoietic Stem Cells

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • Elsevier BV,2013
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:861cc339-9cf1-486d-993e-55b166ec633c
  • https://lup.lub.lu.se/record/4172665URI
  • https://doi.org/10.1016/j.celrep.2013.07.020DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Prospective isolation is critical for understanding the cellular and molecular aspects of stem cell heterogeneity. Here, we identify the cell surface antigen CD9 as a positive marker that provides a simple alternative for hematopoietic stem cell isolation at high purity. Crucially, CD9 affords the capture of all hematopoietic stem cells in murine bone marrow in the absence of contaminating populations that lack authentic stem cell function. Using CD9 as a tool to subdivide hematopoietic stem-cell-containing populations, we provide evidence for heterogeneity at the cellular, functional, and molecular levels.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rörby, EmmaLund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-eml (author)
  • Pina, Cristina (author)
  • Soneji, ShamitLund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-ss3 (author)
  • Reckzeh, Kristian (author)
  • Miharada, KenichiLund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stamcellsmetabolism,Forskargrupper vid Lunds universitet,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,Stem Cell Metabolism,Lund University Research Groups(Swepub:lu)med-kmh (author)
  • Karlsson, ChristineLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Avdelningen för molekylärmedicin och genterapi,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Division of Molecular Medicine and Gene Therapy(Swepub:lu)immu-cgl (author)
  • Guo, Yanping (author)
  • Fugazza, Cristina (author)
  • Gupta, Rajeev (author)
  • Martens, Joost H. A. (author)
  • Stunnenberg, Hendrik G. (author)
  • Karlsson, StefanLund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)molm-ska (author)
  • Enver, Tariq (author)
  • University College LondonAvdelningen för molekylärmedicin och genterapi (creator_code:org_t)

Related titles

  • In:Cell Reports: Elsevier BV4:4, s. 642-6482211-1247

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