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Liver blood dynamic...
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Honka, HenriUniversity of Turku
(author)
Liver blood dynamics after bariatric surgery : The effects of mixed-meal test and incretin infusions
- Article/chapterEnglish2018
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LIBRIS-ID:oai:lup.lub.lu.se:862454a2-461a-45f6-8a1e-cb03155c30b2
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https://lup.lub.lu.se/record/862454a2-461a-45f6-8a1e-cb03155c30b2URI
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https://doi.org/10.1530/EC-18-0234DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Aims/hypothesis: The mechanisms for improved glycemic control after bariatric surgery in subjects with type 2 diabetes (T2D) are not fully known. We hypothesized that dynamic hepatic blood responses to a mixed-meal are changed after bariatric surgery in parallel with an improvement in glucose tolerance. Methods: A total of ten morbidly obese subjects with T2D were recruited to receive a mixed-meal and a glucose-dependent insulinotropic polypeptide (GIP) infusion before and early after (within a median of less than three months) bariatric surgery, and hepatic blood flow and volume (HBV) were measured repeatedly with combined positron emission tomography/MRI. Ten lean non-diabetic individuals served as controls. Results: Bariatric surgery leads to a significant decrease in weight, accompanied with an improved β-cell function and glucagon-like peptide 1 (GLP-1) secretion, and a reduction in liver volume. Blood flow in portal vein (PV) was increased by 1.65-fold (P = 0.026) in response to a mixed-meal in subjects after surgery, while HBV decreased in all groups (P < 0.001). When the effect of GIP infusion was tested separately, no change in hepatic arterial and PV flow was observed, but HBV decreased as seen during the mixed-meal test. Conclusions/interpretation: Early after bariatric surgery, PV flow response to a mixed-meal is augmented, improving digestion and nutrient absorption. GIP influences the post-prandial reduction in HBV thereby diverting blood to the extrahepatic sites.
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Koffert, JukkaUniversity of Turku,Turku University Hospital
(author)
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Kauhanen, SailaTurku University Hospital
(author)
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Kudomi, NobuyukiKagawa University
(author)
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Hurme, SaijaUniversity of Turku
(author)
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Mari, AndreaCNR Institute of Neuroscience, Pisa
(author)
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Lindqvist, AndreasLund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups(Swepub:lu)medk-alt
(author)
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Wierup, NilsLund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups(Swepub:lu)mphy-nwi
(author)
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Parkkola, RiittaTurku University Hospital,University of Turku
(author)
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(author)
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Nuutila, PirjoUniversity of Turku,Turku University Hospital
(author)
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University of TurkuTurku University Hospital
(creator_code:org_t)
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In:Endocrine Connections7:7, s. 888-8962049-3614
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Honka, Henri
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Koffert, Jukka
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Kauhanen, Saila
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Kudomi, Nobuyuki
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Hurme, Saija
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Mari, Andrea
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Lindqvist, Andre ...
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Wierup, Nils
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Parkkola, Riitta
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Groop, Leif
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Nuutila, Pirjo
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Lund University