SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:862454a2-461a-45f6-8a1e-cb03155c30b2"
 

Search: onr:"swepub:oai:lup.lub.lu.se:862454a2-461a-45f6-8a1e-cb03155c30b2" > Liver blood dynamic...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Honka, HenriUniversity of Turku (author)

Liver blood dynamics after bariatric surgery : The effects of mixed-meal test and incretin infusions

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018
  • 9 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:862454a2-461a-45f6-8a1e-cb03155c30b2
  • https://lup.lub.lu.se/record/862454a2-461a-45f6-8a1e-cb03155c30b2URI
  • https://doi.org/10.1530/EC-18-0234DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Aims/hypothesis: The mechanisms for improved glycemic control after bariatric surgery in subjects with type 2 diabetes (T2D) are not fully known. We hypothesized that dynamic hepatic blood responses to a mixed-meal are changed after bariatric surgery in parallel with an improvement in glucose tolerance. Methods: A total of ten morbidly obese subjects with T2D were recruited to receive a mixed-meal and a glucose-dependent insulinotropic polypeptide (GIP) infusion before and early after (within a median of less than three months) bariatric surgery, and hepatic blood flow and volume (HBV) were measured repeatedly with combined positron emission tomography/MRI. Ten lean non-diabetic individuals served as controls. Results: Bariatric surgery leads to a significant decrease in weight, accompanied with an improved β-cell function and glucagon-like peptide 1 (GLP-1) secretion, and a reduction in liver volume. Blood flow in portal vein (PV) was increased by 1.65-fold (P = 0.026) in response to a mixed-meal in subjects after surgery, while HBV decreased in all groups (P < 0.001). When the effect of GIP infusion was tested separately, no change in hepatic arterial and PV flow was observed, but HBV decreased as seen during the mixed-meal test. Conclusions/interpretation: Early after bariatric surgery, PV flow response to a mixed-meal is augmented, improving digestion and nutrient absorption. GIP influences the post-prandial reduction in HBV thereby diverting blood to the extrahepatic sites.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Koffert, JukkaUniversity of Turku,Turku University Hospital (author)
  • Kauhanen, SailaTurku University Hospital (author)
  • Kudomi, NobuyukiKagawa University (author)
  • Hurme, SaijaUniversity of Turku (author)
  • Mari, AndreaCNR Institute of Neuroscience, Pisa (author)
  • Lindqvist, AndreasLund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups(Swepub:lu)medk-alt (author)
  • Wierup, NilsLund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups(Swepub:lu)mphy-nwi (author)
  • Parkkola, RiittaTurku University Hospital,University of Turku (author)
  • Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
  • Nuutila, PirjoUniversity of Turku,Turku University Hospital (author)
  • University of TurkuTurku University Hospital (creator_code:org_t)

Related titles

  • In:Endocrine Connections7:7, s. 888-8962049-3614

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view