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Twins in Guinea-Bis...
Twins in Guinea-Bissau have a 'thin-fat' body composition compared to singletons
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- Wagh, Rucha (author)
- King Edward Memorial Hospital and Research Centre
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- Bjerregaard-Andersen, Morten (author)
- Hospital of South West Jutland, Esbjerg,Odense University Hospital,University of Southern Denmark,Bandim Health Project
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- Bandyopadhyay, Souvik (author)
- Cytel Incorporated
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- Yajnik, Pranav (author)
- Cytel Incorporated
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- Prasad, Rashmi B. (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Otiv, Suhas (author)
- King Edward Memorial Hospital and Research Centre
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- Byberg, Stine (author)
- Steno Diabetes Center Copenhagen,Bandim Health Project
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- Hennild, Ditte Egegaard (author)
- Bandim Health Project
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- Gomes, Gabriel Marciano (author)
- Bandim Health Project
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- Christensen, Kaare (author)
- Odense University Hospital,University of Southern Denmark
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- Sodemann, Morten (author)
- Bandim Health Project,Odense University Hospital
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- Jensen, Dorte Møller (author)
- Odense University Hospital,University of Southern Denmark
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- Yajnik, Chittaranjan S. (author)
- King Edward Memorial Hospital and Research Centre
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(creator_code:org_t)
- 2022
- 2022
- English.
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In: Journal of Developmental Origins of Health and Disease. - 2040-1744. ; 13:6, s. 787-793
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Abstract
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- The 'thrifty phenotype' hypothesis proposed that fetal undernutrition increases risk of diabetes in later life. Undernourished low birthweight Indian babies are paradoxically more adipose compared to well-nourished European babies, and are at higher risk of diabetes in later life. Twin pregnancies are an example of in utero growth restrictive environment due to shared maternal nutrition. There are few studies of body composition in twins. We performed secondary analysis of anthropometric body composition of twins and singletons in Guinea-Bissau, an economically deprived African country. Anthropometric data were available on 7-34 year-old twins (n = 209, 97 males) and singletons (n = 182, 86 males) in the Guinea-Bissau Twin Registry at the Bandim Health Project. Twins had lower birthweight (2420 vs 3100 g, p < 0.001); and at follow-up, lower height (HAZ mean Z-score difference, -0.21, p = 0.055), weight (WAZ -0.73, p = 0.024) and BMI (BAZ -0.22, p = 0.079) compared to singletons but higher adiposity (skinfolds: +0.33 SD, p = 0.001). Twins also had higher fasting (+0.38 SD, p < 0.001) and 2-hour OGTT glucose concentrations (+0.29 SD, p < 0.05). Linear mixed-effect model accounting for intrapair correlations and interactions confirmed that twins were thinner but fatter across the age range. Data on maternal morbidity and prematurity were not available in this cohort. African populations are known to have a muscular (less adipose) body composition. Demonstration of a thin-fat phenotype in twins in a low socio-economic African country supports the thesis that it could be a manifestation of early life undernutrition and not exclusive to Indians. This phenotype could increase risk of diabetes and related conditions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- adiposity
- early life undernutrition
- Guinea-Bissau
- thin-fat
- Twins
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Wagh, Rucha
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Bjerregaard-Ande ...
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Bandyopadhyay, S ...
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Yajnik, Pranav
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Prasad, Rashmi B ...
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Otiv, Suhas
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Byberg, Stine
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Hennild, Ditte E ...
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Gomes, Gabriel M ...
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Christensen, Kaa ...
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Sodemann, Morten
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Jensen, Dorte Mø ...
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Yajnik, Chittara ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Journal of Devel ...
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Lund University