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OARSI/OMERACT Initi...
OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group
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Gossec, Laure (author)
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Paternotte, Simon (author)
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Bingham, Clifton O., III (author)
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Clegg, Daniel O. (author)
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Coste, Philippe (author)
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Conaghan, Philip G. (author)
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Davis, Aileen M. (author)
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Giacovelli, Giampaolo (author)
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Gunther, Klaus-Peter (author)
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Hawker, Gillian (author)
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Hochberg, Marc C. (author)
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Jordan, Joanne M. (author)
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Katz, Jeffrey N. (author)
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Kloppenburg, Margreet (author)
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Lanzarotti, Arturo (author)
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Lim, Keith (author)
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- Lohmander, Stefan (author)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Mahomed, Nizar N. (author)
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Maillefert, Jean Francis (author)
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Manno, Rebecca L. (author)
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March, Lyn M. (author)
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Mazzuca, Steven A. (author)
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Pavelka, Karel (author)
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Punzi, Leonardo (author)
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Roos, Ewa M. (author)
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Rovati, Lucio C. (author)
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Shi, Helen (author)
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Singh, Jasvinder A. (author)
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Suarez-Almazor, Maria E. (author)
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Tajana-Messi, Eleonora (author)
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Dougados, Maxime (author)
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(creator_code:org_t)
- 2011-08-01
- 2011
- English.
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In: Journal of Rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 38:8, s. 1765-1769
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http://dx.doi.org/10...
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https://cdr.lib.unc....
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Abstract
Subject headings
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- Objective. To define pain and physical function cutpoints that would, coupled with structural severity, define a surrogate measure of "need for joint replacement surgery," for use as an outcome measure for potential structure-modifying interventions for osteoarthritis (OA). Methods. New scores were developed for pain and physical function in knee and hip OA. A cross-sectional international study in 1909 patients was conducted to define data-driven cutpoints corresponding to the orthopedic surgeons' indication for joint replacement. A post hoc analysis of 8 randomized clinical trials (1379 patients) evaluated the prevalence and validity of cutpoints, among patients with symptomatic hip/knee OA. Results. In the international cross-sectional study, there was substantial overlap in symptom levels between patients with and patients without indication for joint replacement; indeed, it was not possible to determine cutpoints for pain and function defining this indication. The post hoc analysis of trial data showed that the prevalence of cases that combined radiological progression, high level of pain, and high degree of function impairment was low (2%-12%). The most discriminatory cutpoint to define an indication for joint replacement was found to be [pain (0-100) + physical function (0-100) > 80]. Conclusion. These results do not support a specific level of pain or function that defines an indication for joint replacement. However, a tentative cutpoint for pain and physical function levels is proposed for further evaluation. Potentially, this symptom level, coupled with radiographic progression, could be used to define "nonresponders" to disease-modifying drugs in OA clinical trials. (J Rheumatol 2011;38:1765-9; doi:10.3899/jrheum.110403)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- OSTEOARTHRITIS
- SEVERITY
- PAIN
- FUNCTION
- STRUCTURE OUTCOME MEASURE
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Gossec, Laure
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Paternotte, Simo ...
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Bingham, Clifton ...
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Clegg, Daniel O.
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Coste, Philippe
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Conaghan, Philip ...
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show more...
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Davis, Aileen M.
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Giacovelli, Giam ...
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Gunther, Klaus-P ...
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Hawker, Gillian
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Hochberg, Marc C ...
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Jordan, Joanne M ...
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Katz, Jeffrey N.
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Kloppenburg, Mar ...
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Lanzarotti, Artu ...
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Lim, Keith
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Lohmander, Stefa ...
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Mahomed, Nizar N ...
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Maillefert, Jean ...
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Manno, Rebecca L ...
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March, Lyn M.
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Mazzuca, Steven ...
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Pavelka, Karel
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Punzi, Leonardo
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Roos, Ewa M.
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Rovati, Lucio C.
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Shi, Helen
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Singh, Jasvinder ...
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Suarez-Almazor, ...
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Tajana-Messi, El ...
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Dougados, Maxime
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Journal of Rheum ...
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Lund University