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An Age-Related Expo...
An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood
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- Bonifacio, Ezio (author)
- Dresden University of Technology
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- Weiß, Andreas (author)
- Helmholtz Zentrum München
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Winkler, Christiane (author)
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Hippich, Markus (author)
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- Rewers, Marian J (author)
- University of Northern Colorado
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- Toppari, Jorma (author)
- Turku University Hospital
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- She, Jin-Xiong (author)
- Medical College of Georgia
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- Hagopian, William A (author)
- Pacific Northwest Research Institute
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- Krischer, Jeffrey P (author)
- University of South Florida
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- Vehik, Kendra (author)
- University of South Florida
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- Schatz, Desmond A (author)
- University of Florida
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Ziegler, Anette-Gabriele (author)
- German Center for Diabetes Research,Helmholtz Zentrum München,Klinikum rechts der Isar
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(creator_code:org_t)
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- 2021-02-24
- 2021
- English.
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In: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 44:10, s. 2260-2268
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Abstract
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- OBJECTIVE: Islet autoimmunity develops before clinical type 1 diabetes and includes multiple and single autoantibody phenotypes. The objective was to determine age-related risks of islet autoantibodies that reflect etiology and improve screening for presymptomatic type 1 diabetes.RESEARCH DESIGN AND METHODS: The Environmental Determinants of Diabetes in the Young study prospectively monitored 8,556 genetically at-risk children at 3- to 6-month intervals from birth for the development of islet autoantibodies and type 1 diabetes. The age-related change in the risk of developing islet autoantibodies was determined using landmark and regression models.RESULTS: The 5-year risk of developing multiple islet autoantibodies was 4.3% (95% CI 3.8-4.7) at 7.5 months of age and declined to 1.1% (95% CI 0.8-1.3) at a landmark age of 6.25 years (P < 0.0001). Risk decline was slight or absent in single insulin and GAD autoantibody phenotypes. The influence of sex, HLA, and other susceptibility genes on risk subsided with increasing age and was abrogated by age 6 years. Highest sensitivity and positive predictive value of multiple islet autoantibody phenotypes for type 1 diabetes was achieved by autoantibody screening at 2 years and again at 5-7 years of age.CONCLUSIONS: The risk of developing islet autoimmunity declines exponentially with age, and the influence of major genetic factors on this risk is limited to the first few years of life.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Bonifacio, Ezio
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Weiß, Andreas
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Winkler, Christi ...
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Hippich, Markus
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Rewers, Marian J
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Toppari, Jorma
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show more...
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Lernmark, Åke
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She, Jin-Xiong
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Hagopian, Willia ...
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Krischer, Jeffre ...
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Vehik, Kendra
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Schatz, Desmond ...
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Akolkar, Beena
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Ziegler, Anette- ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes Care
- By the university
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Lund University