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Baseline prostate-s...
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Larsen, Signe Benzon
(author)
Baseline prostate-specific antigen measurements and subsequent prostate cancer risk in the Danish Diet, Cancer and Health cohort
- Article/chapterEnglish2013
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LIBRIS-ID:oai:lup.lub.lu.se:887365c4-ab79-4d82-bfc2-40d7d7435c99
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https://lup.lub.lu.se/record/4062794URI
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https://doi.org/10.1016/j.ejca.2013.04.015DOI
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https://gup.ub.gu.se/publication/178137URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Aim: Although prostate-specific antigen (PSA) screening reduces mortality from prostate cancer, substantial over-diagnosis and subsequent overtreatment are concerns. Early screening of men for PSA may serve to stratify the male population by risk of future clinical prostate cancer. Methods and material: Case-control study nested within the Danish 'Diet, Cancer and Health' cohort of 27,179 men aged 50-64 at enrolment. PSA measured in serum collected at cohort entry in 1993-1997 was used to evaluate prostate cancer risk diagnosed up to 14 years after. We identified 911 prostate cancer cases in the Danish Cancer Registry through 31st December 2007 1:1 age-matched with cancer-free controls. Aggressive cancer was defined as >= T3 or Gleason score >= 7 or N1 or M1. Statistical analyses were based on conditional logistic regression with age as underlying time axis. Results: Total PSA and free-to-total PSA ratio at baseline were strongly associated with prostate cancer risk up to 14 years later. PSA was grouped in quintiles and free-to-total PSA ratio divided in three risk groups. The incidence rate ratio for prostate cancer was 150 (95% confidence interval, 72-310) among men with a total PSA in the highest quintile (>5.1 ng/ml) compared to the lowest (<0.80 ng/ml). The risk of aggressive cancer was highly elevated in men with a PSA level in the highest quintile. The results indicate that one-time measurement of PSA could be used in an individualised screening strategy, sparing a large proportion of men from further PSA-based screening. (C) 2013 Elsevier Ltd. All rights reserved.
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Brasso, Klaus
(author)
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Iversen, Peter
(author)
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Christensen, Jane
(author)
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Christiansen, Michael
(author)
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Carlsson, SigridGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology(Swepub:gu)xcasig
(author)
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Lilja, HansLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-hli
(author)
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Friis, Soren
(author)
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Tjonneland, Anne
(author)
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Dalton, Susanne Oksbjerg
(author)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för urologi
(creator_code:org_t)
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In:European Journal of Cancer: Elsevier BV49:14, s. 3041-30481879-08520959-8049
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Larsen, Signe Be ...
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Brasso, Klaus
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Iversen, Peter
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Christensen, Jan ...
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Carlsson, Sigrid
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Lilja, Hans
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Friis, Soren
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University of Gothenburg