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  • Elbaz, Alexis (author)

Independent and Joint Effects of the MAPT and SNCA Genes in Parkinson Disease

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-03-09
  • Wiley,2011

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:8878d820-0fee-4bdf-808b-b2df4d597a7d
  • https://lup.lub.lu.se/record/1988126URI
  • https://doi.org/10.1002/ana.22321DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:122501356URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective: We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium. Methods: Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case-control and case-only approach. Results: Fifteen GEO-PD sites contributed a total of 5,302 cases and 4,161 controls. All 4 SNCA SNPs and the MAPT H1-haplotype-defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For SNCA, the strongest associations were observed for SNPs located at the 30 end of the gene. There was no evidence of statistical interaction between any of the 4 SNCA SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale. Interpretation: This study confirms the association between PD and both SNCA SNPs and the H1 MAPT haplotype. It shows, based on a variety of approaches, that the joint action of variants in these 2 loci is consistent with independent effects of the genes without additional interacting effects. ANN NEUROL 2011; 69: 778-792

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Ross, Owen A. (author)
  • Ioannidis, John P. A. (author)
  • Soto-Ortolaza, Alexandra I. (author)
  • Moisan, Frederic (author)
  • Aasly, Jan (author)
  • Annesi, Grazia (author)
  • Bozi, Maria (author)
  • Brighina, Laura (author)
  • Chartier-Harlin, Marie-Christine (author)
  • Destee, Alain (author)
  • Ferrarese, Carlo (author)
  • Ferraris, Alessandro (author)
  • Gibson, J. Mark (author)
  • Gispert, Suzana (author)
  • Hadjigeorgiou, Georgios M. (author)
  • Jasinska-Myga, Barbara (author)
  • Klein, Christine (author)
  • Krueger, Rejko (author)
  • Lambert, Jean-Charles (author)
  • Lohmann, Katja (author)
  • van de Loo, Simone (author)
  • Loriot, Marie-Anne (author)
  • Lynch, Timothy (author)
  • Mellick, George D. (author)
  • Mutez, Eugenie (author)
  • Nilsson, ChristerLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-cni (author)
  • Opala, Grzegorz (author)
  • Puschmann, AndreasLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-aps (author)
  • Quattrone, Aldo (author)
  • Sharma, Manu (author)
  • Silburn, Peter A. (author)
  • Stefanis, Leonidas (author)
  • Uitti, Ryan J. (author)
  • Valente, Enza Maria (author)
  • Vilarino-Gueell, Carles (author)
  • Wirdefeldt, KarinKarolinska Institutet (author)
  • Wszolek, Zbigniew K. (author)
  • Xiromerisiou, Georgia (author)
  • Maraganore, Demetrius M. (author)
  • Farrer, Matthew J. (author)
  • Psykiatri, LundSektion IV (creator_code:org_t)

Related titles

  • In:Annals of Neurology: Wiley69:5, s. 778-7921531-82490364-5134

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