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Detecting the vulne...
Detecting the vulnerable carotid plaque : The Carotid Artery Multimodality imaging Prognostic study design
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Gargani, Luna (author)
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- Baldini, Matteo (author)
- University of Pisa
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- Berchiolli, Raffaella (author)
- University of Pisa
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- Bort, Ida Rebecca (author)
- University of Pisa
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Casolo, Giancarlo (author)
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Chiappino, Dante (author)
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- Cosottini, Mirco (author)
- University of Pisa
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D'Angelo, Gennaro (author)
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- De Santis, Mariella (author)
- University of Pisa
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- Erba, Paola (author)
- University Medical Center Groningen,University of Pisa
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Fabiani, Iacopo (author)
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Fabiani, Plinio (author)
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- Gabbriellini, Ilaria (author)
- University of Pisa
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- Galeotti, Gian Giacomo (author)
- University of Pisa
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- Ghicopulos, Irene (author)
- University of Pisa
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- Goncalves, Isabel (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital
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- Lapi, Simone (author)
- University Hospital of Pisa
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- Masini, Gabriele (author)
- University of Pisa
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- Morizzo, Carmela (author)
- University of Pisa
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- Napoli, Vinicio (author)
- University Hospital of Pisa
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- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital
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- Orlandi, Giovanni (author)
- University of Pisa
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- Palombo, Carlo (author)
- University of Pisa
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Pieraccini, Francesco (author)
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- Ricci, Stefano (author)
- University of Florence
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- Siciliano, Gabriele (author)
- University of Pisa
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- Slart, Riemer H.J.A. (author)
- University of Twente,University Medical Center Groningen
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- De Caterina, Raffaele (author)
- University of Pisa
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(creator_code:org_t)
- 2022
- 2022
- English 8 s.
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In: Journal of Cardiovascular Medicine. - 1558-2027. ; 23:7, s. 466-473
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Subject headings
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- BackgroundCarotid artery disease is highly prevalent and a main cause of ischemic stroke and vascular dementia. There is a paucity of information on predictors of serious vascular events. Besides percentage diameter stenosis, international guidelines also recommend the evaluation of qualitative characteristics of carotid artery disease as a guide to treatment, but with no agreement on which qualitative features to assess. This inadequate knowledge leads to a poor ability to identify patients at risk, dispersion of medical resources, and unproven use of expensive and resource-consuming techniques, such as magnetic resonance imaging, positron emission tomography, and computed tomography.ObjectivesThe Carotid Artery Multimodality imaging Prognostic (CAMP) study will: prospectively determine the best predictors of silent and overt ischemic stroke and vascular dementia in patients with asymptomatic subcritical carotid artery disease by identifying the noninvasive diagnostic features of the 'vulnerable carotid plaque'; assess whether 'smart' use of low-cost diagnostic methods such as ultrasound-based evaluations may yield at least the same level of prospective information as more expensive techniques.Study designWe will compare the prognostic/predictive value of all proposed techniques with regard to silent or clinically manifest ischemic stroke and vascular dementia. The study will include ≥300 patients with asymptomatic, unilateral, intermediate degree (40-60% diameter) common or internal carotid artery stenosis detected at carotid ultrasound, with a 2-year follow-up. The study design has been registered on Clinicaltrial.gov on December 17, 2020 (ID number NCT04679727).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- atherosclerosis
- carotid artery disease
- carotid artery plaque
- carotid ultrasound
- magnetic resonance imaging
- stroke
- vascular dementia
- vascular imaging
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Gargani, Luna
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Baldini, Matteo
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Berchiolli, Raff ...
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Bort, Ida Rebecc ...
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Casolo, Giancarl ...
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Chiappino, Dante
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show more...
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Cosottini, Mirco
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D'Angelo, Gennar ...
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De Santis, Marie ...
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Erba, Paola
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Fabiani, Iacopo
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Fabiani, Plinio
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Gabbriellini, Il ...
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Galeotti, Gian G ...
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Ghicopulos, Iren ...
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Goncalves, Isabe ...
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Lapi, Simone
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Masini, Gabriele
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Morizzo, Carmela
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Napoli, Vinicio
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Nilsson, Jan
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Orlandi, Giovann ...
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Palombo, Carlo
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Pieraccini, Fran ...
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Ricci, Stefano
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Siciliano, Gabri ...
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Slart, Riemer H. ...
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De Caterina, Raf ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Journal of Cardi ...
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Lund University