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Association Between...
Association Between Fecal Calprotectin Levels and Small-bowel Inflammation Score in Capsule Endoscopy : A Multicenter Retrospective Study
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- Koulaouzidis, Anastasios (author)
- Royal Infirmary of Edinburgh
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- Sipponen, Taina (author)
- University of Helsinki
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- Nemeth, Artur (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups
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- Makins, Richard (author)
- Gloucestershire Hospitals NHS Foundation Trust
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- Kopylov, Uri (author)
- McGill University
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- Nadler, Moshe (author)
- Tel-Aviv University
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- Giannakou, Andry (author)
- Open University of Cyprus
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- Yung, Diana E (author)
- Royal Infirmary of Edinburgh
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- Johansson, Gabriele Wurm (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups
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- Bartzis, Leonidas (author)
- Royal Infirmary of Edinburgh
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- Thorlacius, Henrik (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Seidman, Ernest G (author)
- McGill University
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- Eliakim, Rami (author)
- Tel-Aviv University
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- Plevris, John N (author)
- Royal Infirmary of Edinburgh
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- Toth, Ervin (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups
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(creator_code:org_t)
- 2016-03-23
- 2016
- English.
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In: Digestive Diseases and Sciences. - : Springer Science and Business Media LLC. - 1573-2568 .- 0163-2116. ; 61:7, s. 2033-2040
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Abstract
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- BACKGROUND: Accurate inflammation reporting in capsule endoscopy (CE) is important for diagnosis and monitoring of treatment of inflammatory bowel disease (IBD). Fecal calprotectin (FC) is a highly specific biomarker of gut inflammation. Lewis score (LS) was developed to standardize quantification of inflammation in small-bowel (SB) CE images.GOALS: Multicenter retrospective study aiming to investigate correlation between LS and FC in a large group of patients undergoing CE for suspected or known small-bowel IBD, and to develop a model for prediction of CE results (LS) based on FC levels.STUDY: Five academic centers and a district general hospital offering CE in UK, Finland, Sweden, Canada, and Israel. In total, 333 patients were recruited. They had small-bowel CE and FC done within 3 months.RESULTS: Overall, correlation between FC and LS was weak (r s: 0.232, P < 0.001). When two clinically significant FC thresholds (100 and 250 μg/g) were examined, the r s between FC and LS was 0.247 (weak) and 0.337 (moderate), respectively (P = 0.307). For clinically significant (LS ≥ 135) or negative (LS < 135) for SB inflammation, ROC curves gave an optimum cutoff point of FC 76 μg/g with sensitivity 0.59 and specificity 0.41.LIMITATIONS: Retrospective design.CONCLUSIONS: LS appears to show low correlation with FC as well as other serology markers of inflammation. FC does not appear to be a reliable biomarker for significant small-bowel inflammation. Nevertheless, FC level ≥ 76 μg/g may be associated with appreciable visual inflammation on small-bowel CE in patients with negative prior diagnostic workup.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Koulaouzidis, An ...
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Sipponen, Taina
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Nemeth, Artur
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Makins, Richard
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Kopylov, Uri
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Nadler, Moshe
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show more...
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Giannakou, Andry
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Yung, Diana E
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Johansson, Gabri ...
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Bartzis, Leonida ...
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Thorlacius, Henr ...
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Seidman, Ernest ...
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Eliakim, Rami
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Plevris, John N
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Toth, Ervin
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Digestive Diseas ...
- By the university
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Lund University