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  • Koulaouzidis, AnastasiosRoyal Infirmary of Edinburgh (author)

Association Between Fecal Calprotectin Levels and Small-bowel Inflammation Score in Capsule Endoscopy : A Multicenter Retrospective Study

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-03-23
  • Springer Science and Business Media LLC,2016

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  • LIBRIS-ID:oai:lup.lub.lu.se:89e7e833-58d5-46b2-812c-8eae45990842
  • https://lup.lub.lu.se/record/89e7e833-58d5-46b2-812c-8eae45990842URI
  • https://doi.org/10.1007/s10620-016-4104-7DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

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  • BACKGROUND: Accurate inflammation reporting in capsule endoscopy (CE) is important for diagnosis and monitoring of treatment of inflammatory bowel disease (IBD). Fecal calprotectin (FC) is a highly specific biomarker of gut inflammation. Lewis score (LS) was developed to standardize quantification of inflammation in small-bowel (SB) CE images.GOALS: Multicenter retrospective study aiming to investigate correlation between LS and FC in a large group of patients undergoing CE for suspected or known small-bowel IBD, and to develop a model for prediction of CE results (LS) based on FC levels.STUDY: Five academic centers and a district general hospital offering CE in UK, Finland, Sweden, Canada, and Israel. In total, 333 patients were recruited. They had small-bowel CE and FC done within 3 months.RESULTS: Overall, correlation between FC and LS was weak (r s: 0.232, P < 0.001). When two clinically significant FC thresholds (100 and 250 μg/g) were examined, the r s between FC and LS was 0.247 (weak) and 0.337 (moderate), respectively (P = 0.307). For clinically significant (LS ≥ 135) or negative (LS < 135) for SB inflammation, ROC curves gave an optimum cutoff point of FC 76 μg/g with sensitivity 0.59 and specificity 0.41.LIMITATIONS: Retrospective design.CONCLUSIONS: LS appears to show low correlation with FC as well as other serology markers of inflammation. FC does not appear to be a reliable biomarker for significant small-bowel inflammation. Nevertheless, FC level ≥ 76 μg/g may be associated with appreciable visual inflammation on small-bowel CE in patients with negative prior diagnostic workup.

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  • Sipponen, TainaUniversity of Helsinki (author)
  • Nemeth, ArturLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups(Swepub:lu)med-aun (author)
  • Makins, RichardGloucestershire Hospitals NHS Foundation Trust (author)
  • Kopylov, UriMcGill University (author)
  • Nadler, MosheTel-Aviv University (author)
  • Giannakou, AndryOpen University of Cyprus (author)
  • Yung, Diana ERoyal Infirmary of Edinburgh (author)
  • Johansson, Gabriele WurmLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups(Swepub:lu)med-giw (author)
  • Bartzis, LeonidasRoyal Infirmary of Edinburgh (author)
  • Thorlacius, HenrikLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)kir-hth (author)
  • Seidman, Ernest GMcGill University (author)
  • Eliakim, RamiTel-Aviv University (author)
  • Plevris, John NRoyal Infirmary of Edinburgh (author)
  • Toth, ErvinLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups(Swepub:lu)ront-eto (author)
  • Royal Infirmary of EdinburghUniversity of Helsinki (creator_code:org_t)

Related titles

  • In:Digestive Diseases and Sciences: Springer Science and Business Media LLC61:7, s. 2033-20401573-25680163-2116

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