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  • Mulders, Peter C.R.Radboud University Nijmegen,Radboud University Medical Center (author)

Structural changes induced by electroconvulsive therapy are associated with clinical outcome

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Elsevier BV,2020
  • 9 s.

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  • LIBRIS-ID:oai:lup.lub.lu.se:8a0ee6ca-a9b1-4646-ad47-38e577f7368a
  • https://lup.lub.lu.se/record/8a0ee6ca-a9b1-4646-ad47-38e577f7368aURI
  • https://doi.org/10.1016/j.brs.2020.02.020DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Electroconvulsive therapy (ECT) is the most effective treatment option for major depressive disorder, so understanding whether its clinical effect relates to structural brain changes is vital for current and future antidepressant research. Objective: To determine whether clinical response to ECT is related to structural volumetric changes in the brain as measured by structural magnetic resonance imaging (MRI) and, if so, which regions are related to this clinical effect. We also determine whether a similar model can be used to identify regions associated with electrode placement (unilateral versus bilateral ECT). Methods: Longitudinal MRI and clinical data (Hamilton Depression Rating Scale) was collected from 10 sites as part of the Global ECT-MRI research collaboration (GEMRIC). From 192 subjects, relative changes in 80 (sub)cortical areas were used as potential features for classifying treatment response. We used recursive feature elimination to extract relevant features, which were subsequently used to train a linear classifier. As a validation, the same was done for electrode placement. We report accuracy as well as the structural coefficients of regions included in the discriminative spatial patterns obtained. Results: A pattern of structural changes in cortical midline, striatal and lateral prefrontal areas discriminates responders from non-responders (75% accuracy, p < 0.001) while left-sided mediotemporal changes discriminate unilateral from bilateral electrode placement (81% accuracy, p < 0.001). Conclusions: The identification of a multivariate discriminative pattern shows that structural change is relevant for clinical response to ECT, but this pattern does not include mediotemporal regions that have been the focus of electroconvulsive therapy research so far.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Llera, AlbertoRadboud University Nijmegen (author)
  • Beckmann, Christian F.University of Oxford,Radboud University Nijmegen (author)
  • Vandenbulcke, MathieuUniversity Hospitals Leuven,Catholic University of Leuven (author)
  • Stek, MaxAmsterdam UMC - Vrije Universiteit Amsterdam,GGZ inGeest Specialized Mental Health Care,Vrije Universiteit Amsterdam (author)
  • Sienaert, PascalUniversity Hospitals Leuven,Catholic University of Leuven (author)
  • Redlich, RonnyUniversity of Münster (author)
  • Petrides, GeorgiosFeinstein Institute for Medical Research,Hofstra University,The Zucker Hillside Hospital (author)
  • Oudega, Mardien LeoniekVrije Universiteit Amsterdam,GGZ inGeest Specialized Mental Health Care,Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Oltedal, LeifUniversity of Bergen,Haukeland University Hospital (author)
  • Oedegaard, Ketil J.Haukeland University Hospital,University of Bergen (author)
  • Narr, Katherine L.University of California, Los Angeles (author)
  • Magnusson, Peter O.Lund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups(Swepub:lu)extLU-696 (author)
  • Kessler, UteHaukeland University Hospital,University of Bergen (author)
  • Jorgensen, AndersUniversity of Copenhagen (author)
  • Espinoza, RandallUniversity of California, Los Angeles (author)
  • Enneking, VerenaUniversity of Münster (author)
  • Emsell, LouiseCatholic University of Leuven,University Hospitals Leuven (author)
  • Dols, AnnemiekeGGZ inGeest Specialized Mental Health Care,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam (author)
  • Dannlowski, UdoUniversity of Münster (author)
  • Bolwig, Tom G.Copenhagen University Hospital (author)
  • Bartsch, HaukeUniversity of California, San Diego,Haukeland University Hospital (author)
  • Argyelan, MiklosFeinstein Institute for Medical Research,Hofstra University,The Zucker Hillside Hospital (author)
  • Anand, AmitCleveland Clinic Foundation (author)
  • Abbott, Christopher C.University of New Mexico (author)
  • van Eijndhoven, Philip F.P.Radboud University Nijmegen,Radboud University Medical Center (author)
  • Tendolkar, IndiraRadboud University Medical Center,Radboud University Nijmegen,University Hospital Essen (author)
  • Radboud University NijmegenRadboud University Medical Center (creator_code:org_t)

Related titles

  • In:Brain Stimulation: Elsevier BV13:3, s. 696-7041935-861X

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