Search: onr:"swepub:oai:lup.lub.lu.se:8a4061fe-01bb-4af7-be44-fe815be80166" > Endogenous androgen...
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000 | 06336naa a2200961 4500 | |
001 | oai:lup.lub.lu.se:8a4061fe-01bb-4af7-be44-fe815be80166 | |
003 | SwePub | |
008 | 160401s2014 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-97271 | |
009 | oai:prod.swepub.kib.ki.se:130099714 | |
024 | 7 | a https://lup.lub.lu.se/record/48719172 URI |
024 | 7 | a https://doi.org/10.1002/ijc.290002 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-972712 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1300997142 URI |
040 | a (SwePub)lud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Ose, Jennifer4 aut |
245 | 1 0 | a Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition |
264 | c 2014-06-16 | |
264 | 1 | b Wiley,c 2014 |
520 | a The role of endogenous androgens and sex hormone-binding globulin (SHBG) in ovarian carcinogenesis is poorly understood. Epithelial invasive ovarian cancer (EOC) is a heterogeneous disease and there are no prospective data on endogenous androgens and EOC risk by tumor characteristics (histology, grade, stage) or the dualistic model of ovarian carcinogenesis (i.e. type I vs. type II, leading to less or more aggressive tumors). We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort evaluating androgens and SHBG and invasive EOC risk by tumor characteristics. Female participants who provided a blood sample and were not using exogenous hormones at blood donation were eligible (n = 183,257). A total of 565 eligible women developed EOC; two controls (n = 1,097) were matched per case. We used multivariable conditional logistic regression models. We observed no association between androgens, SHBG and EOC overall. A doubling of androstenedione reduced risk of serous carcinomas by 21% (odds ratio (OR)log2=0.79, 95% confidence interval [CI]=[0.64-0.97]). Moreover, associations differed for low-grade and high-grade carcinomas, with positive associations for low-grade and inverse associations for high-grade carcinomas (e.g. androstenedione: low grade: ORlog2=1.99 [0.98-4.06]; high grade: ORlog2=0.75 [0.61-0.93], p(het)0.01), similar associations were observed for type I/II tumors. This is the first prospective study to evaluate androgens, SHBG and EOC risk by tumor characteristics and type I/II status. Our findings support a possible role of androgens in ovarian carcinogenesis. Additional studies exploring this association are needed. What's new? There appear to be several types of epithelial invasive ovarian cancer (EOC), and hormone-related risk factors are poorly understood. In this study, the authors found that the impact of endogenous androgens on the risk of developing EOC differed depending upon tumor characteristics. Androgen concentrations were positively associated with the risk of low-grade and type-I carcinomas, but the study found an inverse association for high-grade tumors. These findings support a possible role for androgens in ovarian carcinogenesis, and emphasize the need for additional research. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a ovarian carcinoma | |
653 | a endogenous androgens | |
653 | a histologic subtype | |
653 | a androstenedione | |
653 | a type I tumors | |
653 | a type II tumors | |
653 | a ovarian carcinoma | |
700 | 1 | a Fortner, Renee T.4 aut |
700 | 1 | a Rinaldi, Sabina4 aut |
700 | 1 | a Schock, Helena4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Hansen, Louise4 aut |
700 | 1 | a Dossus, Laure4 aut |
700 | 1 | a Fournier, Agnes4 aut |
700 | 1 | a Baglietto, Laura4 aut |
700 | 1 | a Romieu, Isabelle4 aut |
700 | 1 | a Kuhn, Elisabetta4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Lagiou, Pagona4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Masala, Giovanna4 aut |
700 | 1 | a Sieri, Sabina4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Sacerdote, Carlotta4 aut |
700 | 1 | a Mattiello, Amalia4 aut |
700 | 1 | a Ramon Quiros, Jose4 aut |
700 | 1 | a Obon-Santacana, Mireia4 aut |
700 | 1 | a Larranaga, Nerea4 aut |
700 | 1 | a Chirlaque, Maria-Dolores4 aut |
700 | 1 | a Sanchez, Maria-Jose4 aut |
700 | 1 | a Barricarte, Aurelio4 aut |
700 | 1 | a Peeters, Petra H.4 aut |
700 | 1 | a Bueno-de-Mesquita, H. B(as)4 aut |
700 | 1 | a Onland-Moret, N. Charlotte4 aut |
700 | 1 | a Brändstedt, Jennyu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-jyb |
700 | 1 | a Lundin, Evau Umeå universitet,Patologi,Enheten för biobanksforskning4 aut0 (Swepub:umu)evlu0001 |
700 | 1 | a Idahl, Annikau Umeå universitet,Obstetrik och gynekologi,Näringsforskning,Enheten för biobanksforskning4 aut0 (Swepub:umu)anid0002 |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Gram, Inger T.4 aut |
700 | 1 | a Lund, Eiliv4 aut |
700 | 1 | a Kaw, Kay-Tee4 aut |
700 | 1 | a Travis, Ruth C.4 aut |
700 | 1 | a Merritt, Melissa A.4 aut |
700 | 1 | a Gunther, Marc J.4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
710 | 2 | a Patologi, Malmöb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t International Journal of Cancerd : Wileyg 136:2, s. 399-410q 136:2<399-410x 0020-7136x 1097-0215 |
856 | 4 | u http://dx.doi.org/10.1002/ijc.29000y FULLTEXT |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.29000 |
856 | 4 8 | u https://lup.lub.lu.se/record/4871917 |
856 | 4 8 | u https://doi.org/10.1002/ijc.29000 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97271 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130099714 |
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