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Cutting Edge : Lymp...
Cutting Edge : Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1
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- de Pooter, Renée F. (author)
- University of Chicago
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- Dias, Sheila (author)
- University of Chicago
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- Chowdhury, Munmun (author)
- University of Chicago
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- Bartom, Elisabeth T. (author)
- Northwestern University
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- Okoreeh, Michael K. (author)
- University of Chicago
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- Sigvardsson, Mikael (author)
- Lund University,Lunds universitet,Molekylär lymfopoes,Forskargrupper vid Lunds universitet,Molecular Lymphopoiesis,Lund University Research Groups
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- Kee, Barbara L. (author)
- University of Chicago
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(creator_code:org_t)
- 2019-05-15
- 2019
- English 6 s.
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In: Journal of immunology. - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 202:10, s. 2837-2842
- Related links:
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http://dx.doi.org/10...
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https://www.jimmunol...
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https://doi.org/10.4...
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Abstract
Subject headings
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- Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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