Cutting Edge : Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1

Sigvardsson, Mikael (author): Lund University,Lunds universitet,Molekylär lymfopoes,Forskargrupper vid Lunds universitet,Molecular Lymphopoiesis,Lund University Research Groups

(creator_code:org_t)

2019-05-15
2019
English 6 s.
In: Journal of immunology. - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 202:10, s. 2837-2842

Related links:: http://dx.doi.org/10...; show more...; https://www.jimmunol...; https://lup.lub.lu.s...; https://doi.org/10.4...; show less...

Abstract Subject headings

Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.

By the author/editor: de Pooter, Renée ...; Dias, Sheila; Chowdhury, Munmu ...; Bartom, Elisabet ...; Okoreeh, Michael ...; Sigvardsson, Mik ...; show more...; Kee, Barbara L.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.