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Crystal structure o...
Crystal structure of N-acetylmannosamine kinase from Fusobacterium nucleatum
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- Caing Carlsson, Rhawnie (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Goyal, Parveen, 1984 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Sharma, Amit (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Lund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Ghosh, Swagatha, 1987 (author)
- Institute for Stem Cell Biology and Regenerative Medicine (inStem)
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- Setty, Thanuja Gangi (author)
- Institute for Stem Cell Biology and Regenerative Medicine (inStem),Institute of Trans-Disciplinary Health Sciences and Technology
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- North, Rachel A. (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Canterbury University,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Friemann, Rosmarie, 1975 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Stanford University,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Ramaswamy, S. (author)
- Institute for Stem Cell Biology and Regenerative Medicine (inStem)
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(creator_code:org_t)
- 2017
- 2017
- English 7 s.
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In: Acta crystallographica. Section F, Structural biology communications. - 2053-230X. ; 73:6, s. 356-362
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Abstract
Subject headings
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- Sialic acids comprise a varied group of nine-carbon amino sugars that are widely distributed among mammals and higher metazoans. Some human commensals and bacterial pathogens can scavenge sialic acids from their environment and degrade them for use as a carbon and nitrogen source. The enzyme N-acetylmannosamine kinase (NanK; EC 2.7.1.60) belongs to the transcriptional repressors, uncharacterized open reading frames and sugar kinases (ROK) superfamily. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5′-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. The structure of NanK from Fusobacterium nucleatum was determined to 2.23 Å resolution by X-ray crystallography. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. In spite of the absence of the zinc-binding site, all of the major structural features of enzymatic activity are conserved.
Subject headings
- NATURVETENSKAP -- Biologi -- Strukturbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Structural Biology (hsv//eng)
Keyword
- Fusobacterium nucleatum
- N-acetylmannosamine kinase
- sialic acid catabolism
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Caing Carlsson, ...
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Goyal, Parveen, ...
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Sharma, Amit
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Ghosh, Swagatha, ...
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Setty, Thanuja G ...
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North, Rachel A.
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show more...
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Friemann, Rosmar ...
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Ramaswamy, S.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Structural Biolo ...
- Articles in the publication
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Acta crystallogr ...
- By the university
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Lund University
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University of Gothenburg