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Prognostic value of...
Prognostic value of Alzheimer’s biomarkers in mild cognitive impairment : the effect of age at onset
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- Altomare, Daniele (author)
- Geneva University Hospital,University of Geneva,Univ Geneva, Lab Neuroimaging Aging LANVIE, Geneva, Switzerland;Memory Clin, Univ Hosp Geneva, Geneva, Switzerland
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- Ferrari, Clarissa (author)
- Centro San Giovanni di Dio Fatebenefratelli,IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Serv Stat, Via Pilastroni 4, I-25125 Brescia, Italy
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- Caroli, Anna (author)
- Mario Negri Institute for Pharmacological Research,Ist Ric Farmacol Mario Negri IRCCS, Med Imaging Unit, Bergamo, Italy
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- Galluzzi, Samantha (author)
- Centro San Giovanni di Dio Fatebenefratelli,IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, LANE, Brescia, Italy
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- Prestia, Annapaola (author)
- Centro San Giovanni di Dio Fatebenefratelli,IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, LANE, Brescia, Italy
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- van der Flier, Wiesje M. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam,Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands;Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Epidemiol & Biostat, Amsterdam, Netherlands
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands;Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Radiol & Nucl Med, Amsterdam, Netherlands;Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmo, Sweden
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- Van Berckel, Bart (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands;Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Radiol & Nucl Med, Amsterdam, Netherlands
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- Barkhof, Frederik (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,University College London,Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Radiol & Nucl Med, Amsterdam, Netherlands;UCL, Inst Neurol, London, England;UCL, Inst Healthcare Engn, London, England
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- Teunissen, Charlotte E. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Dept Clin Chem,Neurochem Lab, Amsterdam, Netherlands
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- Wall, Anders (author)
- Uppsala universitet,Uppsala University,Radiologi
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- Carter, Stephen F. (author)
- Karolinska Institute,University of Manchester,Karolinska Inst, Alzheimer Neurobiol Ctr, Stockholm, Sweden;Univ Manchester, Wolfson Mol Imaging Ctr, Manchester, Lancs, England
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- Schöll, Michael (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,University College London,Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmo, Sweden;Univ Gothenburg, Dept Psychiat & Neurochem, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden;UCL, Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, Queen Sq, London, England,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Choo, Il Han (author)
- Karolinska Institute,Chosun University,Karolinska Inst, Alzheimer Neurobiol Ctr, Stockholm, Sweden;Chosun Univ, Sch Med, Dept Neuropsychiat, Gwangju, South Korea
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- Grimmer, Timo (author)
- Technical University of Munich,Tech Univ Munich, Dept Psychiat & Psychotherapy, Klinikum Rechts Isar, Munich, Germany
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- Redolfi, Alberto (author)
- Centro San Giovanni di Dio Fatebenefratelli,IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, LANE, Brescia, Italy
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- Nordberg, Agneta (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden;Karolinska Univ Hosp, Aging Theme, Stockholm, Sweden
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- Scheltens, Philip (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands
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- Drzezga, Alexander (author)
- University of Cologne,Univ Cologne, Dept Nucl Med, Cologne, Germany
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- Frisoni, Giovanni B (author)
- Centro San Giovanni di Dio Fatebenefratelli,Geneva University Hospital,Univ Geneva, Lab Neuroimaging Aging LANVIE, Geneva, Switzerland;IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, LANE, Brescia, Italy;Memory Clin, Univ Hosp Geneva, Geneva, Switzerland
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(creator_code:org_t)
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- 2019-07-02
- 2019
- English 10 s.
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In: Journal of Neurology. - : Springer Science and Business Media LLC. - 0340-5354 .- 1432-1459. ; 266:10, s. 2535-2545
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Abstract
Subject headings
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- Objective: The aim of this study is to assess the impact of age at onset on the prognostic value of Alzheimer’s biomarkers in a large sample of patients with mild cognitive impairment (MCI). Methods: We measured Aβ42, t-tau, hippocampal volume on magnetic resonance imaging (MRI) and cortical metabolism on fluorodeoxyglucose–positron emission tomography (FDG-PET) in 188 MCI patients followed for at least 1 year. We categorised patients into earlier and later onset (EO/LO). Receiver operating characteristic curves and corresponding areas under the curve (AUCs) were performed to assess and compar the biomarker prognostic performances in EO and LO groups. Linear Model was adopted for estimating the time-to-progression in relation with earlier/later onset MCI groups and biomarkers. Results: In earlier onset patients, all the assessed biomarkers were able to predict cognitive decline (p < 0.05), with FDG-PET showing the best performance. In later onset patients, all biomarkers but t-tau predicted cognitive decline (p < 0.05). Moreover, FDG-PET alone in earlier onset patients showed a higher prognostic value than the one resulting from the combination of all the biomarkers in later onset patients (earlier onset AUC 0.935 vs later onset AUC 0.753, p < 0.001). Finally, FDG-PET showed a different prognostic value between earlier and later onset patients (p = 0.040) in time-to-progression allowing an estimate of the time free from disease. Discussion: FDG-PET may represent the most universal tool for the establishment of a prognosis in MCI patients and may be used for obtaining an onset-related estimate of the time free from disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer
- Biomarkers
- Cognition
- FDG-PET
- Imaging
- Alzheimer
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Altomare, Daniel ...
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Ferrari, Clariss ...
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Caroli, Anna
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Galluzzi, Samant ...
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Prestia, Annapao ...
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van der Flier, W ...
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Ossenkoppele, Ri ...
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Van Berckel, Bar ...
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Barkhof, Frederi ...
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Teunissen, Charl ...
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Wall, Anders
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Carter, Stephen ...
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Schöll, Michael
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Choo, Il Han
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Grimmer, Timo
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Redolfi, Alberto
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Nordberg, Agneta
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Scheltens, Phili ...
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Drzezga, Alexand ...
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Frisoni, Giovann ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Neuro ...
- By the university
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Lund University
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Uppsala University
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Karolinska Institutet
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University of Gothenburg