Search: onr:"swepub:oai:lup.lub.lu.se:8b689df2-2992-4e68-8624-8fc3b30ce6f3" >
An open prospective...
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Zawadzki, AntoniLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
(author)
An open prospective study evaluating efficacy and safety of a new medical device for rectal application of activated carbon in the treatment of chronic, uncomplicated perianal fistulas
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2016-11-23
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Springer Science and Business Media LLC,2017
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:8b689df2-2992-4e68-8624-8fc3b30ce6f3
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https://lup.lub.lu.se/record/8b689df2-2992-4e68-8624-8fc3b30ce6f3URI
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https://doi.org/10.1007/s00384-016-2726-zDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135568585URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Purpose: It has been proposed that biological/chemical substances in the intestine might play a role in the occurrence and deterioration of perianal fistulas. Elimination of such unidentified factors from the lower gastrointestinal tract might offer a new strategy for the management of anal fistulas. The aim of this study was to evaluate the clinical effects on non-Crohn’s disease perianal fistula healing, and the safety and tolerability of a new medical device that applies high-purity, high-activity granular activated carbon locally into the rectum twice daily of patients with perianal fistulas without any concomitant medication. Methods: An open, single-arm, prospective study with active treatment for 8 weeks and an optional follow-up until week 24 (ClinicalTrial.govidentifier NCT01462747) among patients with chronic, uncomplicated perianal fistulas scheduled for surgery was conducted. Results: Of 28 patients included, 10 patients (35.7%) showed complete fistula healing (closed, no discharge on palpation) after 8 weeks; seven of these patients, corresponding to 25% of the enrolled patients, remained in remission for up to 31 weeks. At week 8, there was a statistically significant reduction in the discharge visual analog scale (p = 0.04), a significant improvement in the patient-perceived quality of life for the category of embarrassment (p = 0.002), and a trend toward improvement in the other assessment categories. Conclusions: The treatment was well tolerated, and patient acceptance was high. The results support the efficacy and safety of locally administered activated carbon for the treatment of patients with chronic uncomplicated perianal fistulas not receiving any other medication for fistula problems.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Johnson, Louis BankaLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kir-ljo
(author)
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Bohe, MånsLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kir-mbo
(author)
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Johansson, ClaesDanderyd Hospital
(author)
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Ekelund, MatsLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)ma2622ek
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Nielsen, Ole HaagenHerlev Hospital,University of Copenhagen
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KirurgiForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:International Journal of Colorectal Disease: Springer Science and Business Media LLC32:4, s. 509-5120179-19581432-1262
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