Search: onr:"swepub:oai:lup.lub.lu.se:8b7d4ce0-a4bc-443b-a22f-fa3ef7dd86ee" >
Quantitative T-wave...
-
Cortez, DanielLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Minnesota Masonic Children's Hospital,University of Minnesota
(author)
Quantitative T-wave morphology assessment from surface ECG is linked with cardiac events risk in genotype-positive KCNH2 mutation carriers with normal QTc values
- Article/chapterEnglish2019
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:8b7d4ce0-a4bc-443b-a22f-fa3ef7dd86ee
-
https://lup.lub.lu.se/record/8b7d4ce0-a4bc-443b-a22f-fa3ef7dd86eeURI
-
https://doi.org/10.1111/jce.14210DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Introduction: Long QT syndrome (LQTS) mutation carriers have elevated the risk of cardiac events even in the absence of QTc prolongation; however, mutation penetrance in patients with normal QTc may be reflected in abnormal T-wave shape, particularly in KCNH2 mutation carriers. We aimed to assess whether the magnitude of a three-dimensional T-wave vector (TwVM) will identify KCNH2-mutation carriers with normal QTc at risk for cardiac events. Methods: Adult LQT2 patients with QTc < 460 ms in men and <470 ms in women (n = 113, age 42 ± 16 years, 43% male) were compared with genotype-negative family members (n = 1007). The TwVM was calculated using T-wave amplitudes in leads V6, II, and V2 as the square root of (TV62 + TII2 + (0.5*TV2)2). Cox regression analysis adjusted for gender and time-dependent beta-blocker use was performed to assess cardiac event (CE) risk, defined as syncope, aborted cardiac arrest, implantable cardioverter-defibrillator therapy, or sudden death. Results: Dichotomized by median of 0.30 mV, lower TwVM was associated with elevated CE risk compared to those with high TwVM (HR = 2.95, 95% CI, 1.25-6.98, P =.014) and also remained significant after including sex and time-dependent beta-blocker usage in the Cox regression analysis (HR = 2.64, 95% CI, 1.64-4.24, P <.001). However, these associations were found only in women but not in men who had low event rates. Conclusion: T-wave morphology quantified as repolarization vector magnitude using T-wave amplitudes retrieved from standard 12-lead electrocardiogram predicts cardiac events risk in LQT2 women and appears useful for risk stratification of KCNH2-mutation carriers without QTc prolongation.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Zareba, WojciechUniversity of Rochester Medical Center
(author)
-
McNitt, ScottUniversity of Rochester Medical Center
(author)
-
Polonsky, BronislavaUniversity of Rochester Medical Center
(author)
-
Rosero, Spencer Z.University of Rochester Medical Center
(author)
-
Platonov, Pyotr G.Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)kard-ppl
(author)
-
KardiologiSektion II
(creator_code:org_t)
Related titles
-
In:Journal of Cardiovascular Electrophysiology: Wiley30:12, s. 2907-29131045-38731540-8167
Internet link
Find in a library
To the university's database