The course of health-related quality of life after the diagnosis of childhood cancer : a national cohort study

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The course of health-related quality of life after the diagnosis of childhood cancer : a national cohort study

van Gorp, Marloes (author): Princess Maxima Center for Pediatric Oncology/Hematology

Irestorm, Elin (author): Lund University,Lunds universitet,Pediatrisk onkologi,Forskargrupper vid Lunds universitet,Childhood Cancer Research Unit,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Pediatric Oncology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Princess Maxima Center for Pediatric Oncology/Hematology

Twisk, Jos W R (author): Amsterdam Public Health

Dors, Natasja (author): Princess Maxima Center for Pediatric Oncology/Hematology

Mavinkurve-Groothuis, Annelies (author): Princess Maxima Center for Pediatric Oncology/Hematology

Meeteren, Antoinette Y N Schouten van (author): Princess Maxima Center for Pediatric Oncology/Hematology

de Bont, Judith (author): Princess Maxima Center for Pediatric Oncology/Hematology

van den Bergh, Esther M M (author): Princess Maxima Center for Pediatric Oncology/Hematology

van der Meer, Wietske van de Peppel (author): Princess Maxima Center for Pediatric Oncology/Hematology

Beek, Laura R (author): Princess Maxima Center for Pediatric Oncology/Hematology

Aarsen, Femke K (author): Princess Maxima Center for Pediatric Oncology/Hematology

Streefkerk, Nienke (author)

van Litsenburg, Raphaele R L (author)

Grootenhuis, Martha A (author)

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(creator_code:org_t)

2023
2023
English.
In: BMC Cancer. - 1471-2407. ; 23, s. 1-13

Related links:: http://dx.doi.org/10... (free); show more...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND: Comprehensive insight in the longitudinal development of health-related quality of life (HRQOL) after childhood cancer diagnosis could improve quality of care. Thus, we aimed to study the course and biopsychosocial determinants of HRQOL in a unique national cohort of children with cancer.METHODS: HRQOL of 2154 children with cancer was longitudinally reported (median: 3 reports) between diagnosis and 5 years after, using the pediatric quality of life inventory generic core scales (PedsQL). HRQOL was modelled over time since diagnosis using mixed model analysis for children 2-7 years (caregiver-reports) and ≥ 8 years (self-reports). Differences in the course between hematological, solid and central nervous system malignancies were studied. Additional associations of demographics, disease characteristics (age at diagnosis, relapse, diagnosis after the national centralization of childhood cancer care and treatment components) and caregiver distress (Distress thermometer) were studied.RESULTS: Overall, HRQOL improved with time since diagnosis, mostly in the first years. The course of HRQOL differed between diagnostic groups. In children aged 2-7 years, children with a solid tumor had most favorable HRQOL. In children aged ≥ 8 years, those with a hematological malignancy had lower HRQOL around diagnosis, but stronger improvement over time than the other diagnostic groups. In both age-groups, the course of HRQOL of children with a CNS tumor showed little or no improvement. Small to moderate associations (β: 0.18 to 0.67, p < 0.05) with disease characteristics were found. Centralized care related to better HRQOL (β: 0.25 to 0.44, p < 0.05). Caregiver distress was most consistently associated with worse HRQOL (β: - 0.13 to - 0.48, p < 0.01).CONCLUSIONS: The HRQOL course presented can aid in identifying children who have not fully recovered their HRQOL following cancer diagnosis, enabling early recognition of the issue. Future research should focus on ways to support children, especially those with a CNS tumor, for example by decreasing distress in their caregivers.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)

Keyword

Child
Humans
Neoplasms/diagnosis
Cohort Studies
Quality of Life
Hematologic Neoplasms
Self Report

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art (subject category)
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By the author/editor: van Gorp, Marloe ...; Irestorm, Elin; Twisk, Jos W R; Dors, Natasja; Mavinkurve-Groot ...; Meeteren, Antoin ...; show more...; de Bont, Judith; van den Bergh, E ...; van der Meer, Wi ...; Beek, Laura R; Aarsen, Femke K; Streefkerk, Nien ...; van Litsenburg, ...; Grootenhuis, Mar ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

Articles in the publication: BMC Cancer

By the university: Lund University

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