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Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase
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- Kempe, Maria (author)
- Lund University,Lunds universitet,Nanomedicin och biomaterial,Forskargrupper vid Lunds universitet,Nanomedicine and Biomaterials,Lund University Research Groups
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- Mosbach, Klaus (author)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
- (creator_code:org_t)
- Elsevier BV, 1994
- 1994
- English.
- In: Journal of Chromatography A. - : Elsevier BV. - 0021-9673. ; 664:2, s. 276-279
- Journal article (peer-reviewed)
Abstract
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- A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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- art (subject category)
- ref (subject category)
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