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Association between...
Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes
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- Andersen, Marie Louise M. (author)
- Denmark,Danmark
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- Vaziri Sani, Fariba (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Man and Biosphere Health (MABH)
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- Delli, Ahmed (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skane University Hospital,Skånes universitetssjukhus
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- Porksen, Sven (author)
- Denmark,Danmark
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- Jacobssen, Emma (author)
- Skane University Hospital,Skånes universitetssjukhus
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- Thomsen, Jane (author)
- Denmark,Danmark
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- Svensson, Jannet (author)
- Denmark,Danmark
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- Petersen, Jacob Steen (author)
- Denmark,Danmark
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- Hansen, Lars (author)
- Denmark,Danmark
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skane University Hospital,Skånes universitetssjukhus
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- Mortensen, Henrik B. (author)
- Denmark,Danmark
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- Nielsen, Lotte B. (author)
- Denmark,Danmark
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(creator_code:org_t)
- 2012-06-12
- 2012
- English.
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In: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 13:6, s. 454-462
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Abstract
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- Background The zinc transporter 8 (ZnT8) was recently identified as a common autoantigen in type 1 diabetes (T1D) and inclusion of ZnT8 autoantibodies (ZnT8Ab) was found to increase the diagnostic specificity of T1D. Objectives The main aims were to determine whether ZnT8Ab vary during follow-up 1 year after diagnosis, and to relate the reactivity of three types of ZnT8Ab to the residual stimulated C-peptide levels during the first year after diagnosis. Subjects A total of 129 newly diagnosed T1D patients <15 years was followed prospectively 1, 3, 6, and 12 months after diagnosis. Methods Hemoglobin A1c, meal-stimulated C-peptide, ZnT8Ab, and other pancreatic autoantibodies were measured at each visit. Patients were genotyped for the rs13266634 variant at the SLC30A8 gene and HLA-DQ alleles. Results The levels of all ZnT8Ab [ZnT8Arg (arginine), ZnT8Trp (tryptophan), ZnT8Gln (glutamine)] tended to decrease during disease progression. A twofold higher level of ZnT8Arg and ZnT8Gln was associated with 4.6%/5.2% (p = 0.02), 5.3%/8.2% (p = 0.02) and 8.9%/9.7% (p = 0.004) higher concentrations of stimulated C-peptide 3, 6, and 12 months after diagnosis. The TT genotype carriers of the SLC30A8 gene had 45.8% (p = 0.01) and 60.1% (p = 0.002) lower stimulated C-peptide 6 and 12 months after diagnosis compared to the CC and the CT genotype carriers in a recessive model. Conclusions The levels of the Arg variant of the ZnT8 autoantibodies are associated with higher levels of stimulated C-peptide after diagnosis of T1D and during follow-up. Carriers of the TT genotype of the SLC30A8 gene predict lower stimulated C-peptide levels 12 months after diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- residual beta-cell function
- stimulated C-peptide
- SLC30A8
- type 1
- diabetes
- ZnT8 autoantibodies
Publication and Content Type
- art (subject category)
- ref (subject category)
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Andersen, Marie ...
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Vaziri Sani, Far ...
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Delli, Ahmed
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Porksen, Sven
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Jacobssen, Emma
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Thomsen, Jane
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Svensson, Jannet
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Petersen, Jacob ...
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Hansen, Lars
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Lernmark, Åke
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Mortensen, Henri ...
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Nielsen, Lotte B ...
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and Endocrinology an ...
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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MEDICAL AND HEAL ...
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Pediatric Diabet ...
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Lund University
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Kristianstad University College