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Alternative biomark...
Alternative biomarkers for classification of latent tuberculosis infection status in pregnant women with borderline Quantiferon plus results
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- Tesfaye, Fregenet (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Armauer Hansen Research Institute
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- Sturegård, Erik (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Klinisk infektionsmedicin,Clinical Microbiology, Malmö,Lund University Research Groups,Clinical infection medicine
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- Walles, John (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Central Hospital Kristianstad
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- Winqvist, Niclas (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups
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- Balcha, Taye Tolera (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups
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- Karlson, Sara (author)
- Lund University,Lunds universitet,HIV-1 och HIV-2 värd interaktioner,Forskargrupper vid Lunds universitet,HIV-1 and HIV-2 host interactions,Lund University Research Groups
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- Mulleta, Daba (author)
- Adama Public Health Research and Referral Laboratory Center
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- Isberg, Per Erik (author)
- Lund University,Lunds universitet,Statistiska institutionen,Ekonomihögskolan,Department of Statistics,Lund University School of Economics and Management, LUSEM
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- Jansson, Marianne (author)
- Lund University,Lunds universitet,HIV-1 och HIV-2 värd interaktioner,Forskargrupper vid Lunds universitet,HIV-1 and HIV-2 host interactions,Lund University Research Groups
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- Björkman, Per (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Tuberculosis. - : Elsevier BV. - 1472-9792. ; 124
- Related links:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Borderline interferon-gamma (IFN-γ) results (near the cut-off level 0.35 IU/ml) occur in QuantiFERON (QFT) assays. We investigated the performance of alternative biomarkers for classification of latent tuberculosis infection (LTBI) status in pregnant women with borderline QFT IFN-γ responses. Pregnant women (n = 96) were identified from a cohort study in Ethiopia, based on QFT-Plus IFN-γ results (QFT-low: <0.20 IU/ml, n = 33; QFT-borderline: 0.20–0.70 IU/ml, n = 31; QFT-high: >0.70 IU/ml, n = 32), including 12 HIV-positive individuals in each group and with 20 HIV-negative non-pregnant women from the same cohort with QFT IFN-γ <0.20 IU/ml as controls. Concentrations of 8 markers (IL-1ra, IL-6, IL-8, IP-10, MCP-1, MCP-2, osteopontin and resistin) were measured in whole blood QFT supernatants, stimulated separately with TB1 and TB2 antigens. K-nearest neighbor analysis (KNN) was used to classify participants with regard to likelihood of LTBI. Concentrations of MCP-2, IP-10 and IL-1ra were higher in QFT-borderline compared to QFT-low participants in both antigen stimulations (p < 0.001). KNN classification indicated high likelihood of LTBI in 13/31 (42%) women with QFT-borderline IFN-γ results. MCP-2, IP-10 and IL-1ra expressed in whole blood after TB antigen stimulation may be considered as alternative biomarkers for classification of LTBI status in pregnant women with borderline QFT IFN-γ results.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Biomarkers
- Ethiopia
- Gold plus
- Latent tuberculosis
- Pregnancy
- QFT borderline
- Quantiferon
- TB
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tesfaye, Fregene ...
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Sturegård, Erik
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Walles, John
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Winqvist, Niclas
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Balcha, Taye Tol ...
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Karlson, Sara
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show more...
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Mulleta, Daba
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Isberg, Per Erik
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Jansson, Mariann ...
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Björkman, Per
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Tuberculosis
- By the university
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Lund University