Alternative biomarkers for classification of latent tuberculosis infection status in pregnant women with borderline Quantiferon plus results

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Tesfaye, FregenetLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Armauer Hansen Research Institute (author)

Alternative biomarkers for classification of latent tuberculosis infection status in pregnant women with borderline Quantiferon plus results

Article/chapterEnglish2020

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Elsevier BV,2020

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LIBRIS-ID:oai:lup.lub.lu.se:8c85ead3-5e16-41cf-aaaf-b7292d9dad16
https://lup.lub.lu.se/record/8c85ead3-5e16-41cf-aaaf-b7292d9dad16URI
https://doi.org/10.1016/j.tube.2020.101984DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype

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Borderline interferon-gamma (IFN-γ) results (near the cut-off level 0.35 IU/ml) occur in QuantiFERON (QFT) assays. We investigated the performance of alternative biomarkers for classification of latent tuberculosis infection (LTBI) status in pregnant women with borderline QFT IFN-γ responses. Pregnant women (n = 96) were identified from a cohort study in Ethiopia, based on QFT-Plus IFN-γ results (QFT-low: <0.20 IU/ml, n = 33; QFT-borderline: 0.20–0.70 IU/ml, n = 31; QFT-high: >0.70 IU/ml, n = 32), including 12 HIV-positive individuals in each group and with 20 HIV-negative non-pregnant women from the same cohort with QFT IFN-γ <0.20 IU/ml as controls. Concentrations of 8 markers (IL-1ra, IL-6, IL-8, IP-10, MCP-1, MCP-2, osteopontin and resistin) were measured in whole blood QFT supernatants, stimulated separately with TB1 and TB2 antigens. K-nearest neighbor analysis (KNN) was used to classify participants with regard to likelihood of LTBI. Concentrations of MCP-2, IP-10 and IL-1ra were higher in QFT-borderline compared to QFT-low participants in both antigen stimulations (p < 0.001). KNN classification indicated high likelihood of LTBI in 13/31 (42%) women with QFT-borderline IFN-γ results. MCP-2, IP-10 and IL-1ra expressed in whole blood after TB antigen stimulation may be considered as alternative biomarkers for classification of LTBI status in pregnant women with borderline QFT IFN-γ results.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
Biomarkers
Ethiopia
Gold plus
Latent tuberculosis
Pregnancy
QFT borderline
Quantiferon
TB

Added entries (persons, corporate bodies, meetings, titles ...)

Sturegård, ErikLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Klinisk infektionsmedicin,Clinical Microbiology, Malmö,Lund University Research Groups,Clinical infection medicine(Swepub:lu)mmb-est (author)
Walles, JohnLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Central Hospital Kristianstad(Swepub:lu)jo5222ko (author)
Winqvist, NiclasLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups(Swepub:lu)med-nwt (author)
Balcha, Taye ToleraLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups(Swepub:lu)med-ttb (author)
Karlson, SaraLund University,Lunds universitet,HIV-1 och HIV-2 värd interaktioner,Forskargrupper vid Lunds universitet,HIV-1 and HIV-2 host interactions,Lund University Research Groups(Swepub:lu)med-ska (author)
Mulleta, DabaAdama Public Health Research and Referral Laboratory Center (author)
Isberg, Per ErikLund University,Lunds universitet,Statistiska institutionen,Ekonomihögskolan,Department of Statistics,Lund University School of Economics and Management, LUSEM(Swepub:lu)stat-pis (author)
Jansson, MarianneLund University,Lunds universitet,HIV-1 och HIV-2 värd interaktioner,Forskargrupper vid Lunds universitet,HIV-1 and HIV-2 host interactions,Lund University Research Groups(Swepub:lu)mmb-mj0 (author)
Björkman, PerLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)inf-pbj (author)
Klinisk infektionsmedicinForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Tuberculosis: Elsevier BV1241472-9792

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