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Is there a role for...
Is there a role for TNF-alpha antagonists in the treatment of SSc? EUSTAR expert consensus development using the Delphi technique
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Distler, J. H. W. (author)
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Jordan, S. (author)
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Airo, P. (author)
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Alegre-Sancho, J. J. (author)
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Allanore, Y. (author)
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Gurman, A. Balbir (author)
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Caporali, R. (author)
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Caramaschi, P. (author)
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Carreira, P. E. (author)
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Chizzolini, C. (author)
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Cutolo, M. (author)
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Duruoz, M. Tuncay (author)
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Farge-Bancel, D. (author)
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- Hesselstrand, Roger (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Iannone, F. (author)
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De Keyser, F. (author)
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Kucharz, E. J. (author)
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Launay, D. (author)
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de la Pena Lefebvre, P. Garcia (author)
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Lukacova, O. (author)
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Marasini, B. (author)
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Martinovic, D. (author)
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Marques Neto, J. F. (author)
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Radic, M. (author)
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Rednic, S. (author)
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Riemekasten, G. (author)
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Rovensky, J. (author)
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Seidel, M. F. (author)
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Senel, S. (author)
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Smith, V. (author)
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Sunderkoetter, C. (author)
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Ton, E. (author)
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van Laar, J. M. (author)
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Matucci-Cerinic, M. (author)
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Mueller-Ladner, U. (author)
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Distler, O. (author)
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(creator_code:org_t)
- 2011
- 2011
- English.
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In: Clinical and Experimental Rheumatology. - 1593-098X. ; 29:2, s. 40-45
- Related links:
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https://lup.lub.lu.s...
Abstract
Subject headings
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- Objective: To obtain experiences and expert opinion on treatment of SSc patients with TNF-alpha antagonists. Methods: An investigation was carried out among the EUSTAR centres into their expertise on use of TNF-alpha antagonists. Assessment forms on the frequency of TNF-alpha inhibitor use were distributed to EULAR Scleroderma Trials and Research Group (EUSTAR) centres. Afterwards, a three round Delphi exercise was performed to obtain expert consensus on the use of TNF-alpha inhibitors in SSc. Results: Seventy-nine centres returned information on use of TNF-alpha antagonists in SSc patients. A total of 65 patients were treated with TNF-alpha inhibitors in 14 different centres. Forty-eight of the 65 patients treated with TNF-alpha inhibitors improved. Improvement was mainly seen in patients with arthritis, whereas the effects on fibrosis varied. In the first round of the subsequent Delphi approach, 71 out of 79 experts stated that they would use TNF-alpha antagonists in SSc. Arthritis was suggested as an indication for TNF alpha antagonists by 75% of the experts. However; after the third stage of the Delphi exercise, the acceptance for the off-label use of TNF-alpha antagonists decreased and 59% recommended that TNF-alpha antagonists should not be used or only used in clinical trials in SSc patients, while 38% of the experts suggested the use of TNF-alpha antagonists for arthritis associated with SSc. Conclusions: Most of the experts do not recommend the routine use of TNF-alpha antagonists in systemic sclerosis. Arthritis might be a potential indication in SSc, although controlled clinical trials with TNF-alpha antagonists are needed before general recommendations can be given.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- scleroderma
- TNF-alpha
- fibrosis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Distler, J. H. W ...
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Jordan, S.
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Airo, P.
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Alegre-Sancho, J ...
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Allanore, Y.
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Gurman, A. Balbi ...
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show more...
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Caporali, R.
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Caramaschi, P.
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Carreira, P. E.
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Chizzolini, C.
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Cutolo, M.
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Duruoz, M. Tunca ...
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Farge-Bancel, D.
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Hesselstrand, Ro ...
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Iannone, F.
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De Keyser, F.
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Kucharz, E. J.
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Launay, D.
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de la Pena Lefeb ...
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Lukacova, O.
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Marasini, B.
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Martinovic, D.
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Marques Neto, J. ...
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Radic, M.
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Rednic, S.
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Riemekasten, G.
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Rovensky, J.
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Seidel, M. F.
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Senel, S.
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Smith, V.
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Sunderkoetter, C ...
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Ton, E.
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van Laar, J. M.
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Matucci-Cerinic, ...
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Mueller-Ladner, ...
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Distler, O.
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Clinical and Exp ...
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Lund University