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  • Wang, TaoYeshiva University (author)

Pleiotropy of genetic variants on obesity and smoking phenotypes : Results from the Oncoarray Project of The International Lung Cancer Consortium

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-09-28
  • Public Library of Science (PLoS),2017

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:8d88a7cf-499c-46cd-8383-865b8a114742
  • https://lup.lub.lu.se/record/8d88a7cf-499c-46cd-8383-865b8a114742URI
  • https://doi.org/10.1371/journal.pone.0185660DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140903URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Obesity and cigarette smoking are correlated through complex relationships. Common genetic causes may contribute to these correlations. In this study, we selected 241 loci potentially associated with body mass index (BMI) based on the Genetic Investigation of ANthropometric Traits (GIANT) consortium data and calculated a BMI genetic risk score (BMI-GRS) for 17,037 individuals of European descent from the Oncoarray Project of the International Lung Cancer Consortium (ILCCO). Smokers had a significantly higher BMI-GRS than never-smokers (p = 0.016 and 0.010 before and after adjustment for BMI, respectively). The BMI-GRS was also positively correlated with pack-years of smoking (p<0.001) in smokers. Based on causal network inference analyses, seven and five of 241 SNPs were classified to pleiotropic models for BMI/smoking status and BMI/pack-years, respectively. Among them, three and four SNPs associated with smoking status and pack-years (p<0.05), respectively, were followed up in the ever-smoking data of the Tobacco, Alcohol and Genetics (TAG) consortium. Among these seven candidate SNPs, one SNP (rs11030104, BDNF) achieved statistical significance after Bonferroni correction for multiple testing, and three suggestive SNPs (rs13021737, TMEM18; rs11583200, ELAVL4; and rs6990042, SGCZ) achieved a nominal statistical significance. Our results suggest that there is a common genetic component between BMI and smoking, and pleiotropy analysis can be useful to identify novel genetic loci of complex phenotypes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Moon, Jee YoungYeshiva University (author)
  • Wu, YiqunYeshiva University,Peking University (author)
  • Amos, Christopher I.Dartmouth College (author)
  • Hung, Rayjean J.University of Toronto (author)
  • Tardon, AdoninaCIBER Epidemiology and Public Health (CIBERESP),University of Oviedo (author)
  • Andrew, AngelineNorris Cotton Cancer Center,Radboud University Nijmegen (author)
  • Chen, ChuFred Hutchinson Cancer Research Center,Harvard University,Vanderbilt University (author)
  • Christiani, David C.Harvard University (author)
  • Albanes, DemetriosNational Cancer Institute, USA (author)
  • Heijden, Erik H.F.M.van derRadboud University Nijmegen (author)
  • Duell, EricCatalan Institute of Oncology (author)
  • Rennert, GadiCarmel Medical Center (author)
  • Goodman, GaryFred Hutchinson Cancer Research Center (author)
  • Liu, GeoffreyUniversity of Toronto (author)
  • Mckay, James D.International Agency for Research on Cancer, World Health Organization (author)
  • Yuan, Jian MinUniversity of Pittsburgh (author)
  • Field, John K.University of Liverpool (author)
  • Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)smi-jma (author)
  • Grankvist, KjellUmeå universitet,Umeå University,Klinisk kemi(Swepub:umu)kjgr0002 (author)
  • Kiemeney, Lambertus A.Radboud University Nijmegen (author)
  • Marchand, Loic LeUniversity of Hawai'i at Hilo (author)
  • Teare, M. DawnUniversity of Sheffield (author)
  • Schabath, Matthew B.H. Lee Moffitt Cancer Center & Research Institute (author)
  • Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization (author)
  • Aldrich, Melinda C.Vanderbilt University (author)
  • Davies, MichaelUniversity of Liverpool (author)
  • Johansson, MikaelUmeå universitet,Umeå University,Onkologi(Swepub:umu)mijo0025 (author)
  • Tsao, Ming SoundPrincess Margaret Hospital University of Toronto (author)
  • Caporaso, NeilNational Cancer Institute, USA (author)
  • Lazarus, PhilipWashington State University (author)
  • Lam, StephenBritish Columbia Cancer Agency (author)
  • Bojesen, Stig E.Copenhagen University Hospital,University of Copenhagen (author)
  • Arnold, SusanneUniversity of Kentucky (author)
  • Wu, XifengUniversity of Texas (author)
  • Zong, XuchenUniversity of Toronto (author)
  • Hong, Yun ChulSeoul National University (author)
  • Ho, Gloria Y.F.Hofstra University (author)
  • Yeshiva UniversityPeking University (creator_code:org_t)

Related titles

  • In:PLoS ONE: Public Library of Science (PLoS)12:9, s. 0185660-01856601932-6203

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