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- Moparthi, LavanyaLinköpings universitet,Linköping University,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten (author)
Calcium activates purified human TRPA1 with and without its N-terminal ankyrin repeat domain in the absence of calmodulin
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- Elsevier BV,2020
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:8dc9dc9f-89b5-4f90-a76e-1b0ce768d821
- https://lup.lub.lu.se/record/8dc9dc9f-89b5-4f90-a76e-1b0ce768d821URI
- https://doi.org/10.1016/j.ceca.2020.102228DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-169966URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Funding Agencies|Swedish Research CouncilSwedish Research Council [2014-3801]; Medical Faculty of Lund University - ALF [ALFSKANE-451751]; Agence Nationale de la Recherche (ANR)French National Research Agency (ANR) [ANR-17-CE09-0026-01]; European Research Council (ERC) under the European Commissions Seventh Framework Programme [278242]
- Extracellular influx of calcium or release of calcium from intracellular stores have been shown to activate mammalian TRPA1 as well as to sensitize and desensitize TRPA1 electrophilic activation. Calcium binding sites on both intracellular N- and C-termini have been proposed. Here, we demonstrate based on Förster resonance energy transfer (FRET) and bilayer patch-clamp studies, a direct calmodulin-independent action of calcium on the purified human TRPA1 (hTRPA1), causing structural changes and activation without immediate subsequent desensitization of hTRPA1 with and without its N-terminal ankyrin repeat domain (N-ARD). Thus, calcium alone activates hTRPA1 by a direct interaction with binding sites outside the N-ARD.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- Calcium
- Calmodulin
- Pain
- TRP channel
- TRPA1
- Calcium; Calmodulin; TRP channel; TRPA1; Pain
Added entries (persons, corporate bodies, meetings, titles ...)
- Moparthi, Satish BabuPasteur Institute,Inst Pasteur, France (author)
- Wenger, JérômeInstitut Fresnel,Aix-Marseille University,Aix Marseille Univ, France (author)
- Zygmunt, Peter M.Lund University,Lunds universitet,Neurofarmakologi och smärta,Forskargrupper vid Lunds universitet,Neuropharmacology and pain,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)kfar-pzy (author)
- Linköping UniversityAvdelningen för molekylär medicin och virologi (creator_code:org_t)
Related titles
- In:Cell Calcium: Elsevier BV900143-41601532-1991
Internet link
- http://dx.doi.org/10.1016/j.ceca.2020.102228FULLTEXT
- https://doi.org/10.1016/j.ceca.2020.102228
- https://liu.diva-portal.org/smash/get/diva2:1471106/FULLTEXT01.pdffulltext:print
- https://lup.lub.lu.se/record/8dc9dc9f-89b5-4f90-a76e-1b0ce768d821
- https://doi.org/10.1016/j.ceca.2020.102228
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-169966
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