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Familial and hormon...
Familial and hormonal risk factors for papillary serous uterine cancer
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Elit, L (author)
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Pal, T (author)
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Goshen, R (author)
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- Jernström, Helena (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Ackerman, I (author)
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Fyles, A (author)
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Carey, M (author)
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Mitchell, M (author)
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Aube, J (author)
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Narod, SA (author)
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: European Journal of Gynaecological Oncology. - 0392-2936. ; 23:3, s. 187-190
- Related links:
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https://lup.lub.lu.s...
Abstract
Subject headings
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- Objectives: To identify genetic and non-genetic risk factors for papillary serous uterine cancer. Methods: A case-control study was conducted. Case women with papillary serous uterine cancer were compared with two control groups: 1) women with endometrioid uterine cancer and 2) healthy women with no past history of cancer. Cases and controls were matched for age (within two years) and ethnic group. All study subjects completed a questionnaire addressing family history. The cases and healthy controls were assessed for factors associated with estrogen exposure. Results: The risks of breast cancer (RR 1.84, Cl 1.03-331) and of prostate cancer (RR 2.21, CI 0.77-6.37) were higher among the relatives of patients with papillary serous uterine cancer, than among relatives of those with endometrioid uterine cancer. Other significant risk factors included weight at 18 years (p = 0.04) and the use of estrogen replacement therapy (p = 0.04). Conclusion: Relatives of women with papillary serous cancer of the uterus had an increased risk of breast and prostate cancer. Hormonal exposure also increases the risk for this cancer. These Findings suggest that predisposing genetic factors, possibly related to hormone metabolism, may be common to the three forms of cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- hormonal risk factors
- papillary serous uterine cancer
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Elit, L
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Pal, T
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Goshen, R
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Jernström, Helen ...
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Ackerman, I
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Fyles, A
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show more...
-
Carey, M
-
Mitchell, M
-
Aube, J
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Narod, SA
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European Journal ...
- By the university
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Lund University