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Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids
- Danieli, B (author)
- Giardini, A (author)
- Lesma, G (author)
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- Passarella, D (author)
- Silvani, A (author)
- Appendino, G (author)
- Noncovich, A (author)
- Fontana, G (author)
- Bombardelli, E (author)
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- (creator_code:org_t)
- Wiley, 2004
- 2004
- English.
- In: Chemistry and Biodiversity. - : Wiley. - 1612-1872 .- 1612-1880. ; 1:2, s. 327-345
- Journal article (peer-reviewed)
Abstract
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- The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to identify molecular target.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
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- ref (subject category)
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- Danieli, B
- Giardini, A
- Lesma, G
- Passarella, D
- Silvani, A
- Appendino, G
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- Noncovich, A
- Fontana, G
- Bombardelli, E
- Sterner, Olov
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- Lund University
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