onr:"swepub:oai:lup.lub.lu.se:8f827532-4e8c-4bc5-818f-c24556f1195e"
Search: onr:"swepub:oai:lup.lub.lu.se:8f827532-4e8c-4bc5-818f-c24556f1195e" > Cooperation between...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Moller-Kristensen, Mette (author)
Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- 2006-11-29
- Oxford University Press (OUP),2007
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:8f827532-4e8c-4bc5-818f-c24556f1195e
- https://lup.lub.lu.se/record/676276URI
- https://doi.org/10.1093/intimm/dxl131DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The complement system is an important part of the innate immune system. Three pathways, the classical, the alternative and the lectin pathway, lead to the cleavage of complement factor C3, a central event in the activation of the complement system. We investigated the deposition of C3b (solid-phase C3 activation product) on a mannan-coated surface at high concentration of human serum (17%). At these conditions, mannan-binding lectin (MBL) promoted the activation of C3 through the combined action of MBL-associated serine protease (MASP)-1 and MASP-2 without appreciable involvement of the alternative pathway. In serum depleted of MASP-1, MASP-2 and MASP-3, we observed synergetic effect of reconstitution with MASP-1 and MASP-2. This was inhibited by MASP-3. No C3b deposition was observed with C2- or C4-depleted serum. Depletion of factor B had no effect on the MBL-MASP-promoted C3b deposition. Our results demonstrate a function of the orphan protease MASP-1 by providing evidence that this enzyme collaborates with MASP-2 in the generation of C3 convertase, a process observable at high serum concentration, but not at low serum concentration.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- complement
- lectin pathway
- C3 activation
- mannan-binding lectin
Added entries (persons, corporate bodies, meetings, titles ...)
- Thiel, Steffen (author)
- Sjöholm, AndersLund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-asj (author)
- Matsushita, Misao (author)
- Jensenius, Jens C. (author)
- Avdelningen för mikrobiologi, immunologi och glykobiologi - MIGInstitutionen för laboratoriemedicin (creator_code:org_t)
Related titles
- In:International Immunology: Oxford University Press (OUP)19:2, s. 141-1491460-23770953-8178
Internet link
Find in a library
- International Immunology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Moller-Kristense ...
- Thiel, Steffen
- Sjöholm, Anders
- Matsushita, Misa ...
- Jensenius, Jens ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Immunology in th ...
- Articles in the publication
- International Im ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
