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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03407naa a2200337 4500 | |
| 001 | oai:lup.lub.lu.se:8f8e2674-3da6-4ade-ab5b-3dafe20d94ed | |
| 003 | SwePub | |
| 008 | 160401s2005 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/2293502 URI |
| 024 | 7 | a https://doi.org/10.1128/CDLI.12.2.254-258.20052 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Dahlbom, I4 aut |
| 245 | 1 0 | a Immunoglobulin g (IgG) anti-tissue transglutaminase antibodies used as markers for IgA-deficient celiac disease patients |
| 264 | 1 | c 2005 |
| 520 | a The role of immunoglobulin A (IgA) anti-tissue transglutaminase antibodies (IgA-tTG) as predictors of untreated celiac disease (CoD) is well documented, and the presence and levels of these antibodies are most accurately monitored with native or recombinant human antigens. However, IgA-deficient CoD patients are not identified by IgA serology, and conflicting results concerning the diagnostic validity of IgG antibodies against gliadin (IgG-AGA), endomysium (IgG-EmA), and tTG (IgG-tTG) have been reported. The aim of the present study was to evaluate the utility of IgG-tTG for the detection of CoD in IgA-deficient patients. Samples from 115 IgA-deficient and 200 IgA-sufficient subjects were collected and tested for the presence of IgA and IgG antibodies against tTG, EmA, and AGA. Antibodies against tTG were measured by an enzyme-linked immunosorbent assay based on recombinant human tTG, and antibodies against EmA were determined by immunofluorescence. The values for IgG-tTG showed a higher correlation (correlation coefficient [r] = 0.91) with those for IgG-EmA for the IgA-deficient subjects than for the IgA-sufficient subjects (r = 0.88). The overall concordance of the positive and negative results between IgG-tTG and IgG-EmA was 97%, and the IgG-tTG assay discriminated between IgG-EmA-positive and -negative subjects with IgA deficiency at a rate of 100%. Elevated levels of IgG-tTG and IgG-EmA were measured in 70% of the IgA-sufficient subjects. IgG-tTG detection with recombinant human tTG is a good alternative to IgG-EmA detection, and the addition of IgG-tTG assessment to present screening methods may improve the ability to identify IgA-deficient subjects with CoD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 700 | 1 | a Olsson, M4 aut |
| 700 | 1 | a Forooz, NK4 aut |
| 700 | 1 | a Sjoholm, AG4 aut |
| 700 | 1 | a Truedsson, Lennartu Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)mmb-ltr |
| 700 | 1 | a Hansson, T4 aut |
| 710 | 2 | a Avdelningen för mikrobiologi, immunologi och glykobiologi - MIGb Institutionen för laboratoriemedicin4 org |
| 773 | 0 | t Clinical and Diagnostic Laboratory Immunologyg 12:2, s. 254-258q 12:2<254-258x 1071-412X |
| 856 | 4 | u http://dx.doi.org/10.1128/CDLI.12.2.254-258.2005x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/229350 |
| 856 | 4 8 | u https://doi.org/10.1128/CDLI.12.2.254-258.2005 |
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