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- Fonslet, J.Technical University of Denmark (author)
135La as an Auger-electron emitter for targeted internal radiotherapy
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- 2017-12-29
- IOP Publishing,2018
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:8fc94978-3dde-462e-b003-917c1503e0f5
- https://lup.lub.lu.se/record/8fc94978-3dde-462e-b003-917c1503e0f5URI
- https://doi.org/10.1088/1361-6560/aa9b44DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:137375694URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- 135La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, and dosimetry related to 135La therapy. 135La was produced by 16.5 MeV proton irradiation of metallic natBa on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin. The average production rate was 407 19 MBq A-1 (saturation activity), and the radionuclidic purity was 98% at 20 h post irradiation. Chemical separation recovered > 98 % of the 135La with an effective molar activity of 70 20 GBq mol-1. To better assess cellular and organ dosimetry of this nuclide, we have calculated the x-ray and Auger emission spectra using a Monte Carlo model accounting for effects of multiple vacancies during the Auger cascade. The generated Auger spectrum was used to calculate cellular S-factors. 135La was produced with high specific activity, reactivity, radionuclidic purity, and yield. The emission spectrum and the dosimetry are favorable for internal radionuclide therapy.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
- Auger therapy
- isotope production
- La-135
- lanthanum
- radionuclide therapy
Added entries (persons, corporate bodies, meetings, titles ...)
- Lee, B. Q.University of Oxford,Australian National University (author)
- Tran, T. A.Karolinska Institutet,Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund University Bioimaging Center,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-tht (author)
- Siragusa, M.Technical University of Denmark (author)
- Jensen, M.Technical University of Denmark(Swepub:lu)ma1782je (author)
- Kibédi, T.Australian National University (author)
- Stuchbery, A. E.Australian National University (author)
- Severin, G. W.Technical University of Denmark,Michigan State University (author)
- Technical University of DenmarkUniversity of Oxford (creator_code:org_t)
Related titles
- In:Physics in Medicine and Biology: IOP Publishing63:10031-91551361-6560
Internet link
- http://dx.doi.org/10.1088/1361-6560/aa9b44FULLTEXT
- https://backend.orbit.dtu.dk/ws/files/139978360/Fonslet_et_al_2017_Phys._Med._Biol._10.1088_1361_6560_aa9b44.pdf
- https://lup.lub.lu.se/record/8fc94978-3dde-462e-b003-917c1503e0f5
- https://doi.org/10.1088/1361-6560/aa9b44
- http://kipublications.ki.se/Default.aspx?queryparsed=id:137375694
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- Stuchbery, A. E.
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