SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:8fcb67cf-9170-4103-9522-a6a8ab0f71e5"
 

Search: onr:"swepub:oai:lup.lub.lu.se:8fcb67cf-9170-4103-9522-a6a8ab0f71e5" > Enzymatic autoantib...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Hirose, Misa (author)

Enzymatic autoantibody glycan hydrolysis alleviates autoimmunity against type VII collagen

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • Elsevier BV,2012

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:8fcb67cf-9170-4103-9522-a6a8ab0f71e5
  • https://lup.lub.lu.se/record/3481533URI
  • https://doi.org/10.1016/j.jaut.2012.04.002DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Autoantibody-mediated diseases comprise a heterogeneous group of disorders in which the pathogenic potential of autoantibodies has been clearly demonstrated. In general, their treatment relies on the long-term use of systemic corticosteroids and other immunosuppressants that are associated with considerable adverse reactions. EndoS, an endoglycosidase derived from Streptococcus pyogenes, specifically hydrolyzes the N-linked glycan of native IgG and has previously been shown to modulate the interaction between the Fc portion of autoantibody and Fc gamma receptors on leukocytes. Here, different models of autoimmunity to type VII collagen, a structural protein of the dermal-epidermal junction (DEJ), were employed to explore the therapeutic potential of EndoS. First, pretreatment of otherwise pathogenic anti-murine type VII collagen (mCOL7) IgG with EndoS significantly reduced split formation at the DEJ in cryosections of murine skin and abrogated clinical disease in mice. Next, the effect of EndoS was also seen when the enzyme was injected into mice after pathogenic anti-mCOL7 IgG had been administered. Finally, to mimic the patient situation even closer, EndoS was applied in mice that had already developed clinical disease after immunization with mCOL7. In all EndoS-treated mice, disease progression was stopped, and in the majority of mice, clinical disease even regressed. Of note, EndoS was shown to hydrolyze already in vivo-bound pathogenic autoantibodies. In addition, EndoS treatment decreased lesional expression of activating Fc gamma Rs while increasing Fc gamma RIIB expression. (C) 2012 Elsevier Ltd. All rights reserved.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Vafia, Katerina (author)
  • Kalies, Kathrin (author)
  • Groth, Stephanie (author)
  • Westermann, Juergen (author)
  • Zillikens, Detlef (author)
  • Ludwig, Ralf J. (author)
  • Collin, MattiasLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infektion och immunmodulering,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Infection and immunomodulation,Lund University Research Groups(Swepub:lu)medk-mco (author)
  • Schmidt, Enno (author)
  • InfektionsmedicinSektion III (creator_code:org_t)

Related titles

  • In:Journal of Autoimmunity: Elsevier BV39:4, s. 304-3140896-8411

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view