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- Zhou, YingThird Affiliated Hospital of Soochow University (author)
The effects and possible mechanism of action of apolipoprotein M on the growth of breast cancer cells
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- 2021-11-13
- Springer Science and Business Media LLC,2022
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:906d34da-c2c9-45eb-bd1c-aa401b2ae86b
- https://lup.lub.lu.se/record/906d34da-c2c9-45eb-bd1c-aa401b2ae86bURI
- https://doi.org/10.1007/s11033-021-06945-2DOI
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- Language:English
- Summary in:English
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- Background: To investigate the effects and mechanism of action of apolipoprotein M (ApoM) on the growth of breast cancer (BC) cells. Methods and results: Bioinformatics, cell experiments and animal experiments were used to verify the effect of ApoM on breast cancer cell lines and breast tumor growth in vivo. ApoM expression was significantly reduced in BC tissues, and patients with lower ApoM mRNA expression had a poorer prognosis (P < 0.0001). Besides, ApoM can partially inhibit the proliferative, migratory and invasive processes of BC cells. In vivo, the difference between ApoM-OE and NC groups was no significant. The level of vitamin D receptor (VDR) protein in MDA-MB-231 cells was increased by overexpression of ApoM (P < 0.05), while in MCF-7 cells, VDR levels decreased (P < 0.05). Conclusions: ApoM can partially inhibit the growth of BC cells. VDR may play a role, but is not the main pathway.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Apolipoprotein M
- Biological behavior
- Breast cancer
- Tumor in situ
- Vitamin D receptor
Added entries (persons, corporate bodies, meetings, titles ...)
- Yao, ShuangThird Affiliated Hospital of Soochow University (author)
- Yu, MiaomeiThird Affiliated Hospital of Soochow University (author)
- Wei, JiangThird Affiliated Hospital of Soochow University (author)
- Fang, QiThird Affiliated Hospital of Soochow University (author)
- Xu, NingLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kkem-nxu (author)
- Luo, GuanghuaThird Affiliated Hospital of Soochow University (author)
- Third Affiliated Hospital of Soochow UniversityAvdelningen för klinisk kemi och farmakologi (creator_code:org_t)
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- In:Molecular Biology Reports: Springer Science and Business Media LLC49:2, s. 1171-11790301-48511573-4978
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