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The gut microbiota ...
The gut microbiota and diabetes : research, translation, and clinical applications – 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum
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- Byndloss, Mariana (author)
- Vanderbilt University Medical Center
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- Devkota, Suzanne (author)
- Cedars-Sinai Medical Center
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- Duca, Frank (author)
- University of Arizona
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- Niess, Jan Hendrik (author)
- University of Basel
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- Nieuwdorp, Max (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Sanz, Yolanda (author)
- CSIC - Institute Of Agrochemistry And Food Technology (IATA)
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- Tremaroli, Valentina (author)
- University of Gothenburg
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- Zhao, Liping (author)
- Rutgers University: The State University of New Jersey
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Diabetologia. - 0012-186X.
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Abstract
Subject headings
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- This article summarises the state of the science on the role of the gut microbiota (GM) in diabetes from a recent international expert forum organised by Diabetes, Diabetes Care, and Diabetologia, which was held at the European Association for the Study of Diabetes 2023 Annual Meeting in Hamburg, Germany. Forum participants included clinicians and basic scientists who are leading investigators in the field of the intestinal microbiome and metabolism. Their conclusions were as follows: (1) the GM may be involved in the pathophysiology of type 2 diabetes, as microbially produced metabolites associate both positively and negatively with the disease, and mechanistic links of GM functions (e.g. genes for butyrate production) with glucose metabolism have recently emerged through the use of Mendelian randomisation in humans; (2) the highly individualised nature of the GM poses a major research obstacle, and large cohorts and a deep-sequencing metagenomic approach are required for robust assessments of associations and causation; (3) because single time point sampling misses intraindividual GM dynamics, future studies with repeated measures within individuals are needed; and (4) much future research will be required to determine the applicability of this expanding knowledge to diabetes diagnosis and treatment, and novel technologies and improved computational tools will be important to achieve this goal.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Butyrate
- Faecal microbiota transplantation
- Gastrointestinal microbiota
- Gastrointestinal tract microbiology
- Gut microbiota
- Large intestine microbiota
- Metagenomics
- Microbiota metabolites
- Review
- Short-chain fatty acids
- Small intestine microbiota
Publication and Content Type
- for (subject category)
- ref (subject category)
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