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Influence of Polymo...
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Roshandel, Delnaz
(author)
Influence of Polymorphisms in the RANKL/RANK/OPG Signaling Pathway on Volumetric Bone Mineral Density and Bone Geometry at the Forearm in Men
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011-10-02
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Springer Science and Business Media LLC,2011
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:915b18b2-fe38-40b5-800a-db430d065837
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https://lup.lub.lu.se/record/2243172URI
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https://doi.org/10.1007/s00223-011-9532-yDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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We sought to determine the influence of single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG on volumetric bone mineral density (vBMD) and bone geometry at the radius in men. Pairwise tag SNPs (r (2) a parts per thousand yen 0.8) for RANKL (n = 8), RANK (n = 44), and OPG (n = 22) and five SNPs near RANKL and OPG strongly associated with areal BMD in genomewide association studies were previously genotyped in men aged 40-79 years in the European Male Ageing Study (EMAS). Here, these SNPs were analyzed in a subsample of men (n = 589) who had peripheral quantitative computed tomography (pQCT) performed at the distal (4%) and mid-shaft (50%) radius. Estimated parameters were total and trabecular vBMD (mg/mm(3)) and cross-sectional area (mm(2)) at the 4% site and cortical vBMD (mg/mm(3)); total, cortical, and medullary area (mm(2)); cortical thickness (mm); and stress strain index (SSI) (mm(3)) at the 50% site. We identified 12 OPG SNPs associated with vBMD and/or geometric parameters, including rs10505348 associated with total vBMD (beta [95% CI] = 9.35 [2.12-16.58], P = 0.011), cortical vBMD (beta [95% CI] = 5.62 [2.10-9.14], P = 0.002), cortical thickness (beta [95% CI] = 0.08 [0.03-0.13], P = 0.002), and medullary area (beta [95% CI] = -2.90 [-4.94 to -0.86], P = 0.005) and rs2073618 associated with cortical vBMD (beta [95% CI] = -4.30 [-7.78 to -0.82], P = 0.015) and cortical thickness (beta [95% CI] = -0.08 [-0.13 to -0.03], P = 0.001). Three RANK SNPs were associated with vBMD, including rs12956925 associated with trabecular vBMD (beta [95% CI] = -7.58 [-14.01 to -1.15], P = 0.021). There were five RANK SNPs associated with geometric parameters, including rs8083511 associated with distal radius cross-sectional area (beta [95% CI] = 8.90 [0.92-16.88], P = 0.029). No significant association was observed between RANKL SNPs and pQCT parameters. Our findings suggest that genetic variation in OPG and RANK influences radius vBMD and geometry in men.
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Holliday, Kate L.
(author)
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Pye, Stephen R.
(author)
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Ward, Kate A.
(author)
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Boonen, Steven
(author)
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Vanderschueren, Dirk
(author)
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Borghs, Herman
(author)
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Huhtaniemi, Ilpo T.
(author)
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Adams, Judith E.
(author)
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Bartfai, Gyorgy
(author)
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Casanueva, Felipe F.
(author)
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Finn, Joseph D.
(author)
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Forti, Gianni
(author)
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Giwercman, AleksanderLund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups(Swepub:lu)kir-agi
(author)
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Han, Thang S.
(author)
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Kula, Krzysztof
(author)
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Lean, Michael E.
(author)
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Pendleton, Neil
(author)
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Punab, Margus
(author)
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Silman, Alan J.
(author)
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Wu, Frederick C.
(author)
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Thomson, Wendy
(author)
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O'Neill, Terence W.
(author)
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Reproduktionsmedicin, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Calcified Tissue International: Springer Science and Business Media LLC89:6, s. 446-4551432-08270171-967X
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Roshandel, Delna ...
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Holliday, Kate L ...
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Pye, Stephen R.
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Ward, Kate A.
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Boonen, Steven
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Vanderschueren, ...
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Borghs, Herman
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Huhtaniemi, Ilpo ...
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Adams, Judith E.
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Bartfai, Gyorgy
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Casanueva, Felip ...
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Finn, Joseph D.
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Forti, Gianni
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Giwercman, Aleks ...
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Han, Thang S.
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Kula, Krzysztof
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Lean, Michael E.
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Pendleton, Neil
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Punab, Margus
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Silman, Alan J.
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Wu, Frederick C.
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Thomson, Wendy
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O'Neill, Terence ...
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