Pulmonary vascular changes in asthma and COPD.

Harkness, Louise M (author)

Kanabar, Varsha (author)

Sharma, Hari S (author)

Westergren-Thorsson, Gunilla (author): Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups

Larsson Callerfelt, Anna-Karin (author): Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups

(creator_code:org_t)

Elsevier BV, 2014
2014
English.
In: Pulmonary Pharmacology & Therapeutics. - : Elsevier BV. - 1522-9629 .- 1094-5539. ; 29:2, s. 144-155

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Abstract Subject headings

In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review.

By the author/editor: Harkness, Louise ...; Kanabar, Varsha; Sharma, Hari S; Westergren-Thors ...; Larsson Callerfe ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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