Distribution of cortical bone in the femoral neck and hip fracture: A prospective case-control analysis of 143 incident hip fractures; the AGES-REYKJAVIK Study

In this prospective nested case-control study we analyzed the circumferential differences in estimated cortical thickness (Est CTh) of the mid femoral neck as a risk factor for osteoporotic hip fractures in elderly women and men. Segmental QCT analysis of the mid femoral neck was applied to assess cortical thickness in anatomical quadrants. The superior region of the femoral neck was a stronger predictor for hip fracture than the inferior region, particularly in men. There were significant gender differences in Est CTh measurements in the control group but not in the case group. In multivariable analysis for risk of femoral neck (FN) fracture, Est CTh in the supero-anterior (SA) quadrant was significant in both women and men, and remained a significant predictor after adjustment for FN areal BMD (aBMD, dimensions g/cm(2), DXA-like), (p = 0.05 and p<0.0001, respectively). In conclusion, Est CTh in the SA quadrant best discriminated cases (n = 143) from controls (n = 298), especially in men. Cortical thinning superiorly in the hip might be of importance in determining resistance to fracture. (C) 2011 Elsevier Inc. All rights reserved.

Poole, Kenneth E. S. (author)
Reeve, Jonathan (author)
Siggeirsdottir, Kristin (author)
Aspelund, Thor (author)
Mogensen, Brynjolfur (author)
Jonsson, BrynjolfurLund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups(Swepub:lu)med-byj (author)
Sigurdsson, Sigurdur (author)
Harris, Tamara B. (author)
Gudnason, Vilmundur G. (author)
Sigurdsson, Gunnar (author)
Ortopedi - klinisk och molekylär osteoporosforskningForskargrupper vid Lunds universitet (creator_code:org_t)

By the author/editor: Johannesdottir, ...; Poole, Kenneth E ...; Reeve, Jonathan; Siggeirsdottir, ...; Aspelund, Thor; Mogensen, Brynjo ...; show more...; Jonsson, Brynjol ...; Sigurdsson, Sigu ...; Harris, Tamara B ...; Gudnason, Vilmun ...; Sigurdsson, Gunn ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Orthopaedics

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