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Retinoic acid signa...
Retinoic acid signaling in thymic epithelial cells regulates thymopoiesis
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- Wendland, Kerstin (author)
- Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups
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- Niss, Kristoffer (author)
- University of Copenhagen
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- Kotarsky, Knut (author)
- Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups
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- Wu, Nikita Y.H. (author)
- Technical University of Denmark
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- White, Andrea J. (author)
- University of Birmingham
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- Jendholm, Johan (author)
- Technical University of Denmark
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- Rivollier, Aymeric (author)
- Technical University of Denmark
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- Izarzugaza, Jose M.G. (author)
- Technical University of Denmark
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- Brunak, Søren (author)
- University of Copenhagen
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- Holländer, Georg A. (author)
- University of Oxford,University Children's Hospital, Basel,University of Basel
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- Anderson, Graham (author)
- University of Birmingham
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- Sitnik, Katarzyna M. (author)
- Technical University of Denmark
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- Agace, William W. (author)
- Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups,Technical University of Denmark
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(creator_code:org_t)
- 2018-07-15
- 2018
- English 9 s.
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In: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 201:2, s. 524-532
- Related links:
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http://dx.doi.org/10...
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https://www.jimmunol...
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Abstract
Subject headings
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- Despite the essential role of thymic epithelial cells (TEC) in T cell development, the signals regulating TEC differentiation and homeostasis remain incompletely understood. In this study, we show a key in vivo role for the vitamin A metabolite, retinoic acid (RA), in TEC homeostasis. In the absence of RA signaling in TEC, cortical TEC (cTEC) and CD80loMHC class IIlo medullary TEC displayed subset-specific alterations in gene expression, which in cTEC included genes involved in epithelial proliferation, development, and differentiation. Mice whose TEC were unable to respond to RA showed increased cTEC proliferation, an accumulation of stem cell Ag-1hi cTEC, and, in early life, a decrease in medullary TEC numbers. These alterations resulted in reduced thymic cellularity in early life, a reduction in CD4 single-positive and CD8 single-positive numbers in both young and adult mice, and enhanced peripheral CD8+ T cell survival upon TCR stimulation. Collectively, our results identify RA as a regulator of TEC homeostasis that is essential for TEC function and normal thymopoiesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Wendland, Kersti ...
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Niss, Kristoffer
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Kotarsky, Knut
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Wu, Nikita Y.H.
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White, Andrea J.
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Jendholm, Johan
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show more...
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Rivollier, Aymer ...
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Izarzugaza, Jose ...
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Brunak, Søren
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Holländer, Georg ...
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Anderson, Graham
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Sitnik, Katarzyn ...
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Agace, William W ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Journal of Immun ...
- By the university
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Lund University