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Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit.
- Tozzi, Alessandro (author)
- de Iure, Antonio (author)
- Bagetta, Vincenza (author)
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- Tantucci, Michela (author)
- Durante, Valentina (author)
- Quiroga-Varela, Ana (author)
- Costa, Cinzia (author)
- Di Filippo, Massimiliano (author)
- Ghiglieri, Veronica (author)
- Latagliata, Emanuele Claudio (author)
- Wegrzynowicz, Michal (author)
- Giampà, Carmela (author)
- Dalley, Jeffrey W (author)
- Xia, Jing (author)
- Gardoni, Fabrizio (author)
- Mellone, Manuela (author)
- El-Agnaf, Omar Mukhtar (author)
- Ardah, Mustafa Taleb (author)
- Puglisi-Allegra, Stefano (author)
- Spillantini, Maria Grazia (author)
- Picconi, Barbara (author)
- Calabresi, Paolo (author)
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- (creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
- In: Biological Psychiatry. - : Elsevier BV. - 0006-3223.
- Journal article (peer-reviewed)
Abstract
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- Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects induced by early selective overexpression of nigral α-syn are still a matter of debate.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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