Search: onr:"swepub:oai:lup.lub.lu.se:947ec241-eaf6-4032-bd36-9b75bd6d4629" > The major histocomp...
Fältnamn | Indikatorer | Metadata |
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000 | 03542naa a2200433 4500 | |
001 | oai:lup.lub.lu.se:947ec241-eaf6-4032-bd36-9b75bd6d4629 | |
003 | SwePub | |
008 | 160404s2011 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/17778332 URI |
024 | 7 | a https://doi.org/10.1111/j.1365-3083.2010.02493.x2 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Wang, Feng4 aut |
245 | 1 0 | a The major histocompatibility complex (MHC) of the secondary transplant tissue donor influences the cross-reactivity of alloreactive memory cells. |
264 | c 2011-02-08 | |
264 | 1 | b Wiley,c 2011 |
520 | a Memory cells are currently thought to be a major barrier to tolerance induction in transplantation. However, whether alloreactive memory cells resulting from a primary transplant have cross-reactivity in a second transplant is unclear. Here, we used skin transplantation from BALB/c mice donors to pre-sensitize C(57) BL/6 (B6) mice. One month later, several strains of mice (including BALB/c, DBA/2, NOD, C3H and B6 mice) were chosen as donors to construct a memory model of heterotopic cardiac transplantation. The higher degree of MHC mismatch to sensitizing MHC resulted in longer Median survival times (MSTs, BALB/c 3.63 days VS C3H 6.08 days). 3.5 days after cardiac transplantation, compared with the BALB/c and DBA/2 groups, in the groups of NOD and C3H, the infiltration of inflammatory cells in the grafts, the proportion and proliferation of memory cells in spleens, and the function of allogeneic antibodies decreased significantly. The varying degrees of MHC mismatch between the primary and secondary donors influenced the intensity of alloreactive memory cell function, the higher degree of MHC mismatch resulted in better tolerance during secondary transplantation, and these may be related to the changed activation, proliferation and function of the alloreactive memory cells. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
700 | 1 | a Chen, Jibing4 aut |
700 | 1 | a Shao, Wei4 aut |
700 | 1 | a Kang, Xiangpeng4 aut |
700 | 1 | a Xu, Shuo4 aut |
700 | 1 | a Xia, Junjie4 aut |
700 | 1 | a Dai, Helong4 aut |
700 | 1 | a Peng, Yuanzheng4 aut |
700 | 1 | a Thorlacius, Henriku Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-hth |
700 | 1 | a Xing, Jinchun4 aut |
700 | 1 | a Qi, Zhongquanu Lund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-zq0 |
710 | 2 | a Kirurgib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Scandinavian Journal of Immunologyd : Wileyg 73, s. 190-197q 73<190-197x 1365-3083x 0300-9475 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/21204892?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1111/j.1365-3083.2010.02493.xy FULLTEXT |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-3083.2010.02493.x |
856 | 4 8 | u https://lup.lub.lu.se/record/1777833 |
856 | 4 8 | u https://doi.org/10.1111/j.1365-3083.2010.02493.x |
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