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Epigenome-wide asso...
Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes
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- Fragoso-Bargas, Nicolas (author)
- Oslo university hospital
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- Page, Christian M (author)
- Norwegian Institute of Public Health
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- Joubert, Bonnie R (author)
- National Institute of Environmental Health Sciences
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- London, Stephanie J (author)
- National Institute of Environmental Health Sciences
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- Lee-Ødegård, Sindre (author)
- University of Oslo
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- Opsahl, Julia O (author)
- University of Oslo
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- Sletner, Line (author)
- Akershus University Hospital
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- Jenum, Anne K (author)
- University of Oslo
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- Qvigstad, Elisabeth (author)
- Oslo university hospital
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- Prasad, Rashmi B (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki
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- Moen, Gunn-Helen (author)
- University of Queensland
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- Birkeland, Kåre I (author)
- University of Oslo
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- Sommer, Christine (author)
- Oslo university hospital
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(creator_code:org_t)
- Future Medicine Ltd, 2023
- 2023
- English.
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In: Epigenomics. - : Future Medicine Ltd. - 1750-192X .- 1750-1911. ; 15:1, s. 39-52
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Abstract
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- Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. Results & conclusion: cg19888088 (cross-ancestry) in EBF3, cg01952260 (Europeans) and cg07077240 (South Asians) in HERC3 were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in CASC15. The findings were not replicated and were not significant in cord blood.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Fragoso-Bargas, ...
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Page, Christian ...
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Joubert, Bonnie ...
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London, Stephani ...
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Lee-Ødegård, Sin ...
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Opsahl, Julia O
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Sletner, Line
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Jenum, Anne K
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Qvigstad, Elisab ...
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Prasad, Rashmi B
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Moen, Gunn-Helen
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Birkeland, Kåre ...
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Sommer, Christin ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Epigenomics
- By the university
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Lund University