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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04352naa a2200769 4500 | |
| 001 | oai:lup.lub.lu.se:954f2854-6598-4f2d-94ad-7aef449a66b7 | |
| 003 | SwePub | |
| 008 | 160401s2009 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:118289370 | |
| 024 | 7 | a https://lup.lub.lu.se/record/13748762 URI |
| 024 | 7 | a https://doi.org/10.1038/leu.2008.3072 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1182893702 URI |
| 040 | a (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a for2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Dispenzieri, A.4 aut |
| 245 | 1 0 | a International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders |
| 264 | c 2008-11-20 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2009 |
| 520 | a The serum immunoglobulin-free light chain (FLC) assay measures levels of free kappa and lambda immunoglobulin light chains. There are three major indications for the FLC assay in the evaluation and management of multiple myeloma and related plasma cell disorders (PCD). In the context of screening, the serum FLC assay in combination with serum protein electrophoresis (PEL) and immunofixation yields high sensitivity, and negates the need for 24-h urine studies for diagnoses other than light chain amyloidosis (AL). Second, the baseline FLC measurement is of major prognostic value in virtually every PCD. Third, the FLC assay allows for quantitative monitoring of patients with oligosecretory PCD, including AL, oligosecretory myeloma and nearly two-thirds of patients who had previously been deemed to have non-secretory myeloma. In AL patients, serial FLC measurements outperform PEL and immunofixation. In oligosecretory myeloma patients, although not formally validated, serial FLC measurements reduce the need for frequent bone marrow biopsies. In contrast, there are no data to support using FLC assay in place of 24-h urine PEL for monitoring or for serial measurements in PCD with measurable disease by serum or urine PEL. This paper provides consensus guidelines for the use of this important assay, in the diagnosis and management of clonal PCD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a myeloma | |
| 653 | a amyloid | |
| 653 | a immunoglobulin-free light chain | |
| 653 | a prognosis | |
| 700 | 1 | a Kyle, R.4 aut |
| 700 | 1 | a Merlini, G.4 aut |
| 700 | 1 | a Miguel, J. S.4 aut |
| 700 | 1 | a Ludwig, H.4 aut |
| 700 | 1 | a Hajek, R.4 aut |
| 700 | 1 | a Palumbo, A.4 aut |
| 700 | 1 | a Jagannath, S.4 aut |
| 700 | 1 | a Blade, J.4 aut |
| 700 | 1 | a Lonial, S.4 aut |
| 700 | 1 | a Dimopoulos, M.4 aut |
| 700 | 1 | a Comenzo, R.4 aut |
| 700 | 1 | a Einsele, H.4 aut |
| 700 | 1 | a Barlogie, B.4 aut |
| 700 | 1 | a Anderson, K.4 aut |
| 700 | 1 | a Gertz, M.4 aut |
| 700 | 1 | a Harousseau, J. L.4 aut |
| 700 | 1 | a Attal, M.4 aut |
| 700 | 1 | a Tosi, P.4 aut |
| 700 | 1 | a Sonneveld, P.4 aut |
| 700 | 1 | a Boccadoro, M.4 aut |
| 700 | 1 | a Morgan, G.4 aut |
| 700 | 1 | a Richardson, P.4 aut |
| 700 | 1 | a Sezer, O.4 aut |
| 700 | 1 | a Mateos, M. V.4 aut |
| 700 | 1 | a Cavo, M.4 aut |
| 700 | 1 | a Joshua, D.4 aut |
| 700 | 1 | a Turesson, Ingemaru Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)medf-itu |
| 700 | 1 | a Chen, W.4 aut |
| 700 | 1 | a Shimizu, K.4 aut |
| 700 | 1 | a Powles, R.4 aut |
| 700 | 1 | a Rajkumar, S. V.4 aut |
| 700 | 1 | a Durie, B. G. M.4 aut |
| 710 | 2 | a Institutionen för kliniska vetenskaper, Malmöb Medicinska fakulteten4 org |
| 773 | 0 | t Leukemiad : Springer Science and Business Media LLCg 23:2, s. 215-224q 23:2<215-224x 1476-5551x 0887-6924 |
| 856 | 4 | u http://dx.doi.org/10.1038/leu.2008.307y FULLTEXT |
| 856 | 4 | u https://www.nature.com/articles/leu2008307.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1374876 |
| 856 | 4 8 | u https://doi.org/10.1038/leu.2008.307 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:118289370 |
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