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  • Wuestefeld, AnikaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas (author)

Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories

  • BookEnglish2023

Publisher, publication year, extent ...

  • 2023

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  • LIBRIS-ID:oai:lup.lub.lu.se:9556e3ea-d8ee-4fcc-9631-867fa77ad1f4
  • https://lup.lub.lu.se/record/9556e3ea-d8ee-4fcc-9631-867fa77ad1f4URI
  • https://doi.org/10.1101/2023.05.24.542054DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ovr swepub-publicationtype
  • Subject category:vet swepub-contenttype

Notes

  • The medial temporal lobe (MTL) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as Alzheimer's disease neurofibrillary tau tangles. The MTL cortex is composed of several subregions which differ in their functional and cytoarchitectonic features. As neuroanatomical schools rely on different cytoarchitectonic definitions of these subregions, it is unclear to what extent their delineations of MTL cortex subregions overlap. Here, we provide an overview of cytoarchitectonic definitions of the cortices that make up the parahippocampal gyrus (entorhinal and parahippocampal cortices) and the adjacent Brodmann areas (BA) 35 and 36, as provided by four neuroanatomists from different laboratories, aiming to identify the rationale for overlapping and diverging delineations. Nissl-stained series were acquired from the temporal lobes of three human specimens (two right and one left hemisphere). Slices (50 µm thick) were prepared perpendicular to the long axis of the hippocampus spanning the entire longitudinal extent of the MTL cortex. Four neuroanatomists annotated MTL cortex subregions on digitized (20X resolution) slices with 5 mm spacing. Parcellations, terminology, and border placement were compared among neuroanatomists. Cytoarchitectonic features of each subregion are described in detail. Qualitative analysis of the annotations showed higher agreement in the definitions of the entorhinal cortex and BA35, while definitions of BA36 and the parahippocampal cortex exhibited less overlap among neuroanatomists. The degree of overlap of cytoarchitectonic definitions was partially reflected in the neuroanatomists' agreement on the respective delineations. Lower agreement in annotations was observed in transitional zones between structures where seminal cytoarchitectonic features are expressed more gradually. The results highlight that definitions and parcellations of the MTL cortex differ among neuroanatomical schools and thereby increase understanding of why these differences may arise. This work sets a crucial foundation to further advance anatomically-informed human neuroimaging research on the MTL cortex.

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  • Baumeister, HannahGerman Center for Neurodegenerative Diseases (DZNE) Magdeburg (author)
  • Adams, Jenna NUniversity of California, Irvine (author)
  • de Flores, RobinUniversity of Caen Normandy (author)
  • Hodgetts, CarlUniversity of London (author)
  • Mazloum-Farzaghi, NegarUniversity of Toronto (author)
  • Olsen, Rosanna K (author)
  • Puliyadi, VyashJohns Hopkins University (author)
  • Tran, Tammy TStanford University (author)
  • Bakker, Arnold (author)
  • Canada, Kelsey LWayne State University (author)
  • Dalton, Marshall AUniversity of Sydney (author)
  • Daugherty, Ana M (author)
  • Joie, Renaud LaUniversity of California, San Francisco (author)
  • Wang, Lei (author)
  • Bedard, Madigan (author)
  • Buendia, Esther (author)
  • Denning, Amanda (author)
  • Irwin, David J (author)
  • Ittyerah, Ranjit (author)
  • Lee, Edward B (author)
  • Lim, Sydney (author)
  • de Onzoño Martin, Maria Mercedes Iñiguez (author)
  • Lopez, Monica Munoz (author)
  • Schuck, Theresa (author)
  • Trotman, Winifred (author)
  • Vela, Alicia (author)
  • Yushkevich, Paul (author)
  • Amunts, Katrin (author)
  • Augustinack, Jean C (author)
  • Ding, Song-Lin (author)
  • Insausti, Ricardo (author)
  • Kedo, Olga (author)
  • Berron, DavidGerman Center for Neurodegenerative Diseases (DZNE) Magdeburg(Swepub:lu)da1401be (author)
  • Wisse, Laura E MLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,LU Profile Area: Proactive Ageing,Lund University Profile areas(Swepub:lu)la3343wi (author)
  • Klinisk minnesforskningForskargrupper vid Lunds universitet (creator_code:org_t)

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