Increasing plasma fibrinogen, but unchanged levels of intraplatelet cyclic nucleotides, plasma endothelin-1, factor VII, and neopterin during cholesterol lowering with fluvastatin

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:lup.lub.lu.se:957e96f9-fb15-4e26-9b40-888ec20a7417" > Increasing plasma f...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Gottsäter, AndersLund University,Lunds universitet,Skåne University Hospital (author)

Increasing plasma fibrinogen, but unchanged levels of intraplatelet cyclic nucleotides, plasma endothelin-1, factor VII, and neopterin during cholesterol lowering with fluvastatin

Article/chapterEnglish1999

Publisher, publication year, extent ...

Ovid Technologies (Wolters Kluwer Health),1999
8 s.

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:957e96f9-fb15-4e26-9b40-888ec20a7417
https://lup.lub.lu.se/record/957e96f9-fb15-4e26-9b40-888ec20a7417URI
https://doi.org/10.1097/00001721-199904000-00004DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Lipid-lowering statin treatment reduces cardiovascular morbidity and mortality and improves endothelial function in patients with hypercholesterolemia. The aim of the present study was to evaluate plasma levels of fibrinogen, factor VII, and the macrophage-derived inflammatory mediator neopterin during lipid lowering. In addition, the endothelial production of platelet antiaggregatory and vasodilatory factors such as nitric oxide and prostacyclin, and vasoconstrictive factors such as endothelin-1, was assessed. Plasma fibrinogen, factor VII, endothelin-1, and the neopterin and intraplatelet nitric oxide and prostacyclin mediators cyclic 3'-5'guanosine monophosphate (cGMP) and cyclic 3'-5'adenosine monophosphate (cAMP) were measured before and 6 months after the institution of treatment with fluvastatin in 17 patients (eight men and nine women, median age 60 years) with vascular disease and previously untreated hypercholesterolemia. After 6 months, a decrease of 1.62 mmol/l [1.26-2.18 (19%); P < 0.01] was noted in levels of total cholesterol, and a decrease of 1.70 mmol/l [1.52-2.30 (28%); P < 0.01] in levels of low-density lipoprotein cholesterol. Plasma levels of fibrinogen had increased [from 4.81 g/l (4.26- 5.27) to 5.17 g/l (4.81-5.67); P < 0.05], whereas no significant changes had occurred in intraplatelet levels of cGMP [decrease by 0.05 pmol/109 platelets (-0.17 to 0.24); NS], cAMP [decrease by 0.13 pmol/109 platelets (- 0.37 to 0.86); NS], plasma endothelin-1 [decrease by 0.05 pg/ml (-0.60 to 0.70); NS], plasma factor VII [from 1.14 IE/ml (0.58-1.38) to 1.22 IE/ml (0.96-1.46); NS], or plasma neopterin [from 8.6 nmol/l (7.1-11.5) to 8.7 nmol/l (7.9-11.3); NS]. In conclusion, during cholesterol-lowering treatment with fluvastatin, plasma levels of fibrinogen increased whereas intraplatelet cyclic nucleotide levels and plasma endothelin-1, factor VII and neopterin levels were unchanged.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
cGMP
Cholesterol
Coagulation
Endothelin- 1
Fibrinogen cAMP
Fluvastatin
Inflammation

Added entries (persons, corporate bodies, meetings, titles ...)

Anwaar, I.Skåne University Hospital (author)
Lind, P.Lund University,Lunds universitet,Skåne University Hospital(Swepub:lu)extLU-1418 (author)
Mattiasson, I.Lund University,Lunds universitet,Skåne University Hospital(Swepub:lu)medf-im0 (author)
Lindgärde, F.Lund University,Lunds universitet,Skåne University Hospital(Swepub:lu)medf-fli (author)
Lunds universitetSkåne University Hospital (creator_code:org_t)

Related titles

In:Blood Coagulation and Fibrinolysis: Ovid Technologies (Wolters Kluwer Health)10:3, s. 133-1400957-5235

Internet link

Find in a library

Blood Coagulation and Fibrinolysis (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Gottsäter, Ander ...; Anwaar, I.; Lind, P.; Mattiasson, I.; Lindgärde, F.

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

Articles in the publication: Blood Coagulatio ...

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se